Substances of polypeptide nature useful in human therapy

Details Substances of polypeptide nature useful in human therapy Substances of polypeptide nature useful in human therapy

1995-03-13

1998-10-20

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530353, A61K 3802, C07K 1446

Patent

active

058246401

ABSTRACT:
Substances of polypeptide nature are obtainable by extraction with HClO.sub.4 and 3M KCl from animal tissue homogenates. The substances have the characteristics of (a) molecular weights ranging from 10,000 to 50,000 daltons (by polyacrylamide gel electrophoresis); (b) are capable of inducing the formation of antibodies which specifically bind in vivo or in vitro antigens which are present in human tumoral cells, when administered to different animal species; (c) are capable of decreasing or inhibiting pain; (d) induce an effect of cell lysis; and (e) inhibit or slow tumor growth, when administered to humans affected by malignant tumors of different kinds.

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Chemical Abstracts, vol. 106, No. 23, issued Jun. 8, 1987, Abstract #194 775g, T. Nishihara, et al--"Novel Antitumor Polypeptide Production" etc.
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Schweizerische Rundschau Fur Medizin Praxis, vol. 79, No. 16, Apr. 17, 1990, A. Kast et al, "Faktor AF2--die vierte Saule in der Tumortherapie" etc., pp. 498-502.

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