Substances K01-B0171 and process for producing the same

Details Substances K01-B0171 and process for producing the same Substances K01-B0171 and process for producing the same

2003-01-17

2008-10-21

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S315000

Reexamination Certificate

active

07439225

ABSTRACT:
The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.

REFERENCES:
patent: 4374764 (1983-02-01), Arai et al.
Hart et al., Australian and New Zealand Journal of Medicine, 1988, vol. 18, No. 6, pp. 790-791.
Miyakawa, Y. et al., “In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis”, Infection and Immunity, (1996), vol. 64, No. 3, pp. 926 to 932, abstract.
Hart, D.H. et al., “Lung infection caused byRhodococcus”, Australian and New Zealand Journal of Medicine, (Oct. 1988), vol. 18, No. 6, pp. 790 to 791, abstract.
A. Maureen Rouhi, Chemical and Engineering News, May 17, pp. 52-69, 1999.
N. Saitou et al., “The Neighbor-joining Method: A New Method for Reconstructing Phylogenetic Trees”, Mol. Biol. Evol. 4: 406-425, 1987.

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