Substances and their uses

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S387300, C530S387900, C530S388150, C530S388240, C530S389200, C530S350000

Reexamination Certificate

active

06919432

ABSTRACT:
A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated by viruses. They may also be useful in preventing graft rejection and in protecting stem cells from potentially damaging effects of chemotherapy.

REFERENCES:
patent: 5011912 (1991-04-01), Hopp et al.
patent: 6150132 (2000-11-01), Wells et al.
patent: WO 92/20372 (1992-11-01), None
patent: WO 94/07521 (1994-04-01), None
patent: WO 94/11504 (1994-05-01), None
patent: WO 94/21277 (1994-09-01), None
patent: WO 94/29348 (1994-12-01), None
Charo, Israel F. et al., “Molecular Cloning and Functional Expression of Two Monocyte . . .”, Proc. Natl. Acad. Sci. USA, vol. 94, cell Biology, Mar. 1994, pp. 2752-2756.
Gao, Ji-Liang et al., “Structure and Functional Expression of the Human . . .”, Jour al of Experimental Medicine, vol. 177, May 1993, pp. 1421-1427.
Gao, Ji-Liang et al., “Human Cytomegalovirus Open Reading Frame US28 . . .”, Journal of Biological Chemistry, vol. 269, No. 46, Nov. 18, 1994, pp. 28539-28542.
Graham, G. J. et al., “Identification and Characterization of an Inhibitor . . .”, Nature, vol. 344, Mar. 29, 1990, pp. 442-444.
Libert et al, “Selective amplification and cloning of four new members of the G protein-coupled receptor family”, Science 244:569-572 (1989).
Yamagami et al, “cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor”, Biochemical and Biophysical Research Communications 202(2):1156-1162 (1994).
Neote et al, “Molecular cloning, functional characteristics of a CC chemokine receptor”, Cell 72:415-425 (1993).
Power et al, “Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line”, Journal of Biological Chemistry 270(33):19495-19500 (1995).
Gieorge et al, “Macromolecular Sequencing and Synthesis”, Alan R. Liss, Inc. pp 127-149 (1988).
Jones et al. “Replacing the complementarity-determining regions in a human antibody with those from a mouse” Nature 321:522-525 (1986).
Riechmann et al. “Reshaping human antibodies for therapy” Nature 332:323-327 (1988).
Bischoff et al (1993) “RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors” Eur J Immunol 23:761-767.
Charo et al. (1994) “Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails” Proc Natl Acad Sci USA 91:2752-2756.
Chvatchko et al (2000) “A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock” J Exp Med 191:1755-1763.
Gao et al (1993) “Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor” J Exp Med 177:1421-1427.
Gao et al (1994) “Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor” J Biol Chem 269:28539-28542.
George et al (1988) “Current methods in sequence comparison and analysis” In:Macromolecular Sequencing and Synthesis, D.H. Schlesinger (ed). ALan R. Liss, New York, pp 127-149 (1988).
Graham et al (1990) “Identification and characterization of an inhibitor of haemopoietic stem cell proliferation” Nature 344:442-444.
Kawasaki et al (2001) “Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsive in Mice” J Immunol 166:2055-2062.
Libert et al (1989) “Selective amplification and cloning of four new members of the G protein-coupled receptor family” Science 244:569-572.
Neote et al (1993) “Molecular cloning, functional characteristics of a CC chemokine receptor” Cell 72:415-425.
Panina-Bordignon et al (2001) “The C-C chemokine receptors CCr4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics” J Clin Invest 107:1357-1364.
Power et al (1995) “Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line” J Biol Chem 270:19495-19500.
Yamagami et al (1994) “cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor” Biochem Biophys Res Comm 202:1156-1162.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substances and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substances and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substances and their uses will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3420638

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.