Substance with interleukin-8 inhibiting activity and process for

Details Substance with interleukin-8 inhibiting activity and process for Substance with interleukin-8 inhibiting activity and process for

1991-01-16

1993-08-10

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, 530351, 530412, 530842, A61K 3702, C07K 302, C07K 1506

Patent

active

052349110

ABSTRACT:
A substance is prepared having interleukin-8 inhibiting activity by extracting psoriatic scales and separating the extract on several successive HPLC columns, using an assay for IL-8i activity based on the inhibition of myeloperoxidase release and/or of the neutrophil chemotaxis of a reference sample.
The substance is suitable for the preparation of anti-inflammatory medicines.

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Siegbahn et al., Scand. J. Haematol., vol. 35(1), pp. 80-87 (1985) (Abstract).
Miller et al., FASEB (Fed. Am. Soc. Exp. Biol.) J4 (7), 1990, A2117.
Donabedian et al., Infect. Immun., vol. 40 (3), pp. 1030-1037 (1983).
Bacon et al, Biochem. Biophys. Res. Comm., vol. 169 (3), pp. 1099-1104 (1990).
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Dinarello et al., New Engl. J. Med. (1987) 317:940-945.
Schroder, J. Exp. Med. (1989) 847-863.
Schroder et al., J. Immunol. (1987) 139:3474-3483.

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