Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2004-04-16
2009-10-27
Gabel, Gailene R (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387300, C530S388150, C530S388220
Reexamination Certificate
active
07608695
ABSTRACT:
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.
REFERENCES:
patent: 4444879 (1984-04-01), Foster et al.
patent: 5321127 (1994-06-01), Handin
patent: 5585243 (1996-12-01), Aster et al.
patent: 6790823 (2004-09-01), Simonet et al.
patent: 6878811 (2005-04-01), Fukuchi et al.
patent: 8-333400 (1996-12-01), None
patent: WO 91/09614 (1991-07-01), None
patent: WO 93/16712 (1993-09-01), None
patent: WO 96/18412 (1996-06-01), None
patent: WO 97/23614 (1997-07-01), None
patent: WO 97/24440 (1997-07-01), None
Lopez et al., Cloning of the alpha chain of human platelet glycoprotein lb: a transmembrane. Proc. Natl. Acad. Sci. USA 84: 5615-5619 (Dec. 28, 1987).
M.O. Spycher, et al., “The Calcium-Dependent Neutral Protease of Human Blood Platelets: A Comparison of its Effects on the Receptors for Von Willebrand Factor ANF for the Fc-Fragment Derived From IgG”, Adv. Exp. Med. Biol., vol. 167 (1984), pp. 241-251.
Groupe V et al., Experiences in the search for anti-inflammatory agents of microbial origin. Journal of Antibiotics, (Dec. 1977) 30 (12) 1080-6 (Abstract).
Tamura et al., A new genus of the order Actinomycetales, Couchioplanes gen. nov., with descriptions of Couchioplanes caeruleus and Couchioplanes caeruleus subsp. azureus. Intl. Journal of Systematic Bacteriology, 44(2): 193-203, Apr., 1994 (Abstract).
Miura et al., Inhibition assay for the binding of biotinylated vWF to ristocetin or botrocetin, Ana. Biochem. 236(2): 1996, pp. 215-220.
Handa, M., et al., The vWF binding domain of GPIb, J. Biol. Chem. 261:12579-12585 (1986).
T. Moriki et al., Expression and Functional characterization of an abdominal platelet membrane GPlba reported in patients with platelet typed vWF disease, Blood, vol. 90: 698-705 (1997).
Minamoto et al., Detection of Platelet Adhesion/Aggregation to Immobilized Ligands on Microbeads by an Aggregometer, (Thrombosis and Haemostasls, 76(6): 1072-1079 (1996)).
Eefke J. Petersen, et al., “Functional Expression of Single Chain Glycoprotein lb Alpha on the Surface of COS Cells and BHK Cells”, Thrombosis and Haemostasis, XP-008034765, vol. 76, No. 5, 1996, pp. 768-773.
Vicente Vicente, et a., Isolation and Functional Characterization of the von Willebrand Factor-binding Domain Located between Residues His1-Arg293of the alpha-chain of Glycoprotein lb, The Journal of Biological Chemistry, XP-002294509vo1. 263, No. 34, Dec. 5, 1988, pp. 18473-18479 9.
Taei Matsui, et al., “Interaction of von Willerbrand Factor with the Extracellular Matrix and Glycocalicin under Static Conditions” J. Biochem, XP-001194786,vol. 121, No. 2, Feb. 1997, pp. 376-381.
Vicente Vicente, et al., “Identification of a Site in the α Chain of Platelet Glycoprotein lb That Participates in von Villebrand Factor Binding”, The Journal of Biological Chemistry, vol. 265, No. 1, Issue of Jan. 5, pp. 274-280, 1990.
Fukuchi Naoyuki
Futaki Fumie
Ishii Koichi
Jojima Yasuko
Kajiura Takayuki
Ajinomoto Co. Inc.
Gabel Gailene R
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
LandOfFree
Substance with antithrombotic activity and method for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substance with antithrombotic activity and method for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substance with antithrombotic activity and method for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4057568