Substance with antithrombotic activity and method for...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007210, C435S007800, C435S007920, C435S069100, C435S069600, C436S506000, C436S507000, C436S513000, C436S517000, C436S544000, C436S545000, C436S546000, C436S172000, C436S501000, C436S519000, C436S520000, C530S383000, C530S385000, C530S388100, C530S388200

Reexamination Certificate

active

06878811

ABSTRACT:
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.

REFERENCES:
patent: 5321127 (1994-06-01), Handin
patent: 5585243 (1996-12-01), Aster et al.
patent: 8-333400 (1996-12-01), None
Minamoto et al., Detection of Platelet Adhesion/Aggregation to Immobilized Ligands on Microbeads by an Aggregometer, (Thrombosis and Haemostasis, 76(6): 1072-1079 (1996)).*
Groupe V et al., Experiences in the search for anti-inflammatory agents of microbial origin. Journal of Antibiotics, (Dec. 1977) 30 (12) 1080-6 (Abstract).*
Tamura et al., A new genus of the order Actinomycetales, Couchioplanes gen. nov., with descriptions of Couchioplanes caeruleus and Couchioplanes caeruleus subsp. azureus. Intl Journal of Systematic Bacteriology, 44(2): 193-203, Apr., 1994 (Abstract).*
Miura et al., Inhibition assay for the binding of biotinylated vWF to ristocetin or botrocetin, Ana. Biochem. 236(2): 1996, pp. 215-220.*
Handa, M., et al., The vWF binding domain of GPIb, J. Biol. Chem. 261:12579-12585 (1986).*
T. Moriki et al., Expression and Functional characterization of an abnormal platelet membrane GPIba reported in patients with platelet type vWF diseae, Blood, vol. 90: 698-705 (1997).*
M.O. Spycher, et al., “The Calcium-Dependent Neutral Protease of Human Blood Platelets: A Comparison of its Effects on The Receptors for Von Willebrand Factor ANF for The Fc-Fragment Derived From IgG”, Adv. Exp. Med. Biol., vol. 167 (1984), pp. 241-251.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substance with antithrombotic activity and method for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substance with antithrombotic activity and method for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substance with antithrombotic activity and method for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3414981

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.