Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-04-12
2005-04-12
Chin, Christopher L. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S007100, C435S007210, C435S007800, C435S007920, C435S069100, C435S069600, C436S506000, C436S507000, C436S513000, C436S517000, C436S544000, C436S545000, C436S546000, C436S172000, C436S501000, C436S519000, C436S520000, C530S383000, C530S385000, C530S388100, C530S388200
Reexamination Certificate
active
06878811
ABSTRACT:
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.
REFERENCES:
patent: 5321127 (1994-06-01), Handin
patent: 5585243 (1996-12-01), Aster et al.
patent: 8-333400 (1996-12-01), None
Minamoto et al., Detection of Platelet Adhesion/Aggregation to Immobilized Ligands on Microbeads by an Aggregometer, (Thrombosis and Haemostasis, 76(6): 1072-1079 (1996)).*
Groupe V et al., Experiences in the search for anti-inflammatory agents of microbial origin. Journal of Antibiotics, (Dec. 1977) 30 (12) 1080-6 (Abstract).*
Tamura et al., A new genus of the order Actinomycetales, Couchioplanes gen. nov., with descriptions of Couchioplanes caeruleus and Couchioplanes caeruleus subsp. azureus. Intl Journal of Systematic Bacteriology, 44(2): 193-203, Apr., 1994 (Abstract).*
Miura et al., Inhibition assay for the binding of biotinylated vWF to ristocetin or botrocetin, Ana. Biochem. 236(2): 1996, pp. 215-220.*
Handa, M., et al., The vWF binding domain of GPIb, J. Biol. Chem. 261:12579-12585 (1986).*
T. Moriki et al., Expression and Functional characterization of an abnormal platelet membrane GPIba reported in patients with platelet type vWF diseae, Blood, vol. 90: 698-705 (1997).*
M.O. Spycher, et al., “The Calcium-Dependent Neutral Protease of Human Blood Platelets: A Comparison of its Effects on The Receptors for Von Willebrand Factor ANF for The Fc-Fragment Derived From IgG”, Adv. Exp. Med. Biol., vol. 167 (1984), pp. 241-251.
Fukuchi Naoyuki
Futaki Fumie
Ishii Koichi
Kito Morikazu
Tanaka Akiko
Ajinomoto Co. Inc.
Chin Christopher L.
Gabel Gailene R.
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