Substance that specifically recognizes PD-1

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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07858746

ABSTRACT:
Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality.

REFERENCES:
patent: 5629204 (1997-05-01), Honjo et al.
patent: 7029674 (2006-04-01), Carreno et al.
patent: WO 01/14557 (2001-03-01), None
patent: WO 02/078731 (2002-10-01), None
Okazaki T., et al., PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine, Proc. Natl. Acad. Sci., USA, 2001, 98(24):13866-13871.
Freeman, G.J., et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J. Exp. Med., 2000, 192(7): 1027-1034.
Nishimura, et al., Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses, Int. Immunol., 1998, 10(10):1562-1572.
XP-001064842—(2001) Yvette Latchman et al., “PD-L2 is a second ligand for PD-1 and inhibits T cell activation”, Nature Immunology, Nature Publishing Group, vol. 2, No. 3, pp. 261-268.
XP-002189416—(2001) Su-Yi Tseng et al., “B7-DC, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells”, J. Exp. Med., vol. 193, No. 7, pp. 839-845.
XP-000971788—(1999) Hiroyuki Nishimura et al., “Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor”, Cell Press, vol. 11, No. 2, pp. 141-151.
XP-002973917—(2002) Julia Brown et al., “Blockade of PD-1 ligands on dendritic cells enhances T cell activation and cytokine production”, Federation of American Societies for Experimental Biology, vol. 16, No. 4, A710, 5174.
Partial European Search Report dated Dec. 5, 2005.
Abbas, et al., Cellular and Molecular Immunology, 2003, Elsevvier Science, pp. 114-171.
Webster's New World Dictionary, 1988, Simon & Schuster, pp. 1121 and 1335.
Blazar, et al., J. Immunol., 1996, 157:3250-3259.
Bach J., Immunology Today, 1993, 14:322-326.

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