Substance TH69E and immunopotentiator containing the same

Details Substance TH69E and immunopotentiator containing the same Substance TH69E and immunopotentiator containing the same

1982-02-24

1985-09-24

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435170, A61K 3574, C12P 104

Patent

active

045432597

ABSTRACT:
A substance TH69E having the following characteristics: (a) elementary analysis: C: 24.25%, H: 4.46% and N: 6.55%; (b) molecular weight: about 60,000.+-.15,000 (Biogel P-Series Column); (c) color: white amorphous powder; (d) decomposition point: 180.degree. C. (as determined by a capillary method with use of Silicone Oil WF-30--the color changes to brown); (e) ultraviolet absorption spectrum: as shown in FIG. 1 of the drawings; (f) infrared absorption spectrum: as shown in FIG. 2 of the drawings; (g) pH: 6.7 to 7.1 in an aqueous solution; (h) solubility: soluble in water, and insoluble in ethanol, acetone, n-hexane, n-butanol and phenol; and (i) color reactions: phenol-sulfuric acid reaction, anthrone reaction, Molisch reaction, orcinol-hydrochloric acid reaction, Ninhydrin reaction being positive, and Elson-Morgan's reaction being negative. The substance TH69E exhibits immunopotentiating activities such as a collagen decomposition enhancing effect, an infection preventive effect and an interferon inducing effect.

REFERENCES:
Nippon Acta Radiologica, 40, No. 5, 507, (1980).
Acta Histochem. Cytochem., 1979, Part I, 591.
Nippon Acta Radiologica, 40, Supplement, 89, (1980).
Japanese Journal of Bacteriology, 35, No. 1, 306, (1980).
Japanese Journal of Bacteriology, 35, No. 6, 779, (1980).
Proceedings of the Japanese Cancer Association, 40th Annual Meeting, 106, (1981).
Proceedings of the Society of Japanese Virologists, 29th Annual Meeting, 1082, (1981).

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