Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-07-07
2000-09-05
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 314985
Patent
active
061143316
ABSTRACT:
Use of a substance according to formula (I) including its tautomeric forms, stereoisomeric forms and salts ##STR1## for the production of a drug suppressing the immunoreaction, in particular suppressing allograft rejection.
REFERENCES:
S. Pfeiffer et al.: "Allosteric and Functional Effects of the Potent Pterin Antagonist of Neronal nitric Oxide Synthase 4-Amino-Tetrahydrobiopterin";Portland Press Proc., vol. 15, No. Biology of Nitric Oxide, part 6, 1998, p. 15 XP002088812, the whole document.
E.R. Werner et al.; "Identification of the 4-Amino analogue of Tetrahydrobiopterin as a Dihydropteridine Reductase Inhibitornand a Potent PteridineAntagonist of Rat Neuronal Nitric Oxide Synthase"; Biochem. J., vol. 320, No. 1, 1996, pp. 193-196, XP00208813, the whole document.
B. Meyer et al.: "Tetrahydrobiopterin binding to Macrophage Inducible Nitric Oxide synthase: Heme Spin Shift and Dimer Stabilization by the Potent Pterin Antagonist 4-Amino-Tetrahydrobiopterin"; Biochemistry, vol. 36, No. 27, 1997, pp. 8422-8427, XP002088814, abstract.
S. Pfeiffer et al.: "Allosteric Modulatipon of Rat Brain Nitric Oxide Synthase by the Pterin-Site Enzyme Inhibitor 4-Aminotetrahydrobiopterin"; Biochem. J., vol. 328, No. 2, 1997, pp. 349-352, XP002088815, abstract.
Chemical Abstracts, vol. 128, No. 26, Jun. 29, 1998, Columbus, Ohio, U.S.; avbstract No. 318679e, E.R. Werner et al.: "Binding of Pteridines to Nitric Oxide synthase by Tetrahydrobiopterin"; p. 239; XP002088816, abstract & Chem. Biol. Pteridines Folates 1997, pp. 669-673.
LandOfFree
Substance suppressing allograft rejection does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substance suppressing allograft rejection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substance suppressing allograft rejection will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2212363