Substance quantification in animal bodies

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378 18, G01D 1800

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active

048376868

ABSTRACT:
A system and method is disclosed for utilizing image pixel value information generated by a digital radiographic system for quantifying the amount of calcium in a particular object of interest within a subject, wherein the subject also contains additional quantities of calcium located at positions such that the additional calcium interfers with the acquisition of data describing the object of interest. A cursor configured as a parallelogram is described and pixel values are summed along lines parallel to the sides of the parallelogram. A profile is generated from these summations. A portion of the profile corresponding to pixel lines not intersecting the object of interest is used to estimate the contribution of background and other calcium to the profile as a whole, and this estimated value is subtracted from the total profile. Integration of the remainder of the profile provides a scalar value corresponding to the amount of calcium in the object of interest.

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O'Keefe, M. E., "Calcification in Solitary Nodules of the Lung".
Joseph, P. M., "An Improved Algorithm for Reprojecting Rays Through Pixel Images".
"Principles of Interactive Computer Graphics", McGraw-Hill, pp. 22-25.
Kruger, R. A., "Dual Energy Film Subtraction Technique for Detecting Calcification in Solitary Pulmonary Nodules".
Tarver, R. D., "Experimental Lung Nodule Model: CT Numbers, Nodule Size, and Actual Calcium Content".
Siegelman, S. S., "CT of the Solitary Pulmonary Nodule".

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