Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1997-03-28
1999-08-31
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
514 15, A61K 3808
Patent
active
059455080
ABSTRACT:
Substance P aerosols are effective in replenishing immune systems compromised by environmental toxicants. They are also useful for prophylaxis against and treatment of infections and neoplasms. They are useful for accelerating maturation of immune systems or maintaining immune function, as well. Chronic exposure to hydrocarbons is particularly damaging to the immune system, and thus this occupational hazard can be counteracted by treatment with substance P aerosols.
REFERENCES:
patent: 5256765 (1993-10-01), Leong
patent: 5410019 (1995-04-01), Coy et al.
patent: 5610176 (1997-03-01), Horwell
Elizabeth M. Kudlacz et al., "In Vitro and in vivo effects of Tachykinins on Immune Cell Function in Guinea Pig Airways" Journal of Neuroimmunology, vol. 50, No. 2, Mar. 1994, pp. 119-125.
David T. Harris et al. "Protection from JP-8 Jet Fuel Induced Immunotoxicity by Administration of Aerosolized Substance P" Toxicology and Industrial Health, vol. 13, No. 5, 1997, pp. 571-588.
Orosz, Int'l J. Cancer 60, 82, 1995.
Everard, European J. Cancer 29A, 1450, 1993.
Reeve, Biochem Biophys Res Comm 199, 1313, 1994.
Flageole, J. Surg. Res. 53, 445, 1992.
Woll, Cancer Research 50, 3968, 1990.
Cummings, Biochem Pharmacol 49, 1709, 1995.
Pranela Rameshwar et al. "Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by Substance P" Journal of Neuroimmunology, 37 (1992) 65-74.
Charles-Felix Calvo et al. "Substance P Enhances IL-2 Expression in Activated Human T Cells" Journal of Immunology, vol. 148 3498-3504 No. 11, Jun. 1, 1992.
Donald G. Payan et al. "Specific Stimulation of Human T Lymphocytes by Substance P" Journal of Immunology vol. 131, No. 4, Oct. 1983, pp. 1613-1615.
Joseph P. McGillis et al. "Substance P and Immunoregulation" Federation Proceedings 1987 vol. 46, pp. 196-199.
Lotz et al., "B Cell Stimulating Factor 2/Interleukin 6 is a Costimulant for Human Thymocytes and T Lymphocytes", J. Exp. Med., 167:1253-1258 (1988).
Tammy Kincy-Cain et al., "Substance P-Induced 1L-12 Production by Murine Macrophages", The American Association of Immunologists, 158(5)2334-2339 (1997).
Xiao-Ying Yu, "Protective effect of substance P on permeability of airway epithelial cells in culture", American Physiological Society 889-895, (1996).
Garman et al., "B-Cell-Stimulatory Factor 2 (.beta..sub.2 Interferon) Functions as a Second Ssignal for Interleukin 2 Production bvy Mature Murine T Cells", Proc. Natl. Acad. Sci. USA 84:7629-7633 (1987).
Pfaff et al., "Inhalation Exposure to JP-8 Jet Fuel Alters Pulmonary Function and Substance P Levels in Fischer 344 Rats", J. Appl. Toxicol 15(4):249-256 (1995).
Lotz et al., "Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes", Science 241:1218-1221 (1988).
Kincy-Cain et al., Increased Susceptibility of Mice to Salmonella Infection Following In Vivo Treatment with the Substance P Antagonist, Spantide II, The Journal of Immunology, 157:255-264, 1996.
Palermo et al., "Bronchospasm Induced by Inhalation of Substance P: Effect of Sodium Cromoglycate", Respiration 54:95-99 (1988).
Boichot et al., "Inhaled Substance P Induces Actgivation of Alveolar Macrophages and Increases Airway Responses in the Guinea-Pig", Neorpeptides 25(307-313 (1993).
Pfaff et al, "Neutral Endopeptidase (NEP) and its Role in Pathological Pulmonary Change with Inhalation Exposure to JP-8 Jet Fuel", Toxicology and Industrial Health 12(1):93-103 (1996).
Jurjus A, Walsh R, "Detection of substance P positive cells and nerve fibers in the rat thymus, " The Faseb Journal, 11(3):A201, 1997.
Hays et al., "Changes in Lung Permeability Correlate with Lung Histology in a Chronic Exposure Model", Toxicology and Industrial Health 11(3):325-336 (1995).
Harris David T.
Witten Mark L.
Lukton David
Tsang Cecilia J.
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