Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from arthropod
Reexamination Certificate
2000-10-24
2002-11-19
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from arthropod
C424S537000, C424S725000, C424S744000, C424S746000
Reexamination Certificate
active
06482442
ABSTRACT:
The invention relates to the topical use of a substance mixture comprising honey and olive oil.
“Topical” here means the local, external treatment of skin parts. By applying a substance or a substance mixture onto the area to be treated, the ingredients can directly penetrate at the diseased location and act there. The alleviating and healing properties thus can become active immediately and precisely localized.
Agents presently in use for the treatment of hemorrhoids (node-shaped enlargement of the branches of the arteria or vena rectalis sup. in the region of the corpora cavernosa recti supplied with arterial or venous blood) very often contain corticoids whose use, however, on account of the severe side effects, involves great difficulties and risks. At present, there also exist some corticoid-free medicaments, such as Acetonal-Hämorrhoidal®, Hädensa®, Mucotherm-Zäpfchen® (suppositories), Sperti Präparation® or Sulgan®, to mention but a few, wherein a hypersensitivity to one of the components of these preparations may occur with any one of them. With the two last mentioned medicaments, however, also allergic reactions may occur. Furthermore, these agents do not lead to a quick and certain healing, but in most cases have an alleviating effect only.
The loss of hair may have various causes, it may, e.g., be caused by old age, or it may be a consequence of radiation or chemotherapy in tumour treatment. Dandruff may be caused by external influences or by internal or infectious diseases. A number of agents have been described for hair and scalp care, such as, e.g., capsules to be swallowed, electrical pulses for activating cell functions, hair lotions, shampoos or hair packs. These treatments have to be carried out over longer periods of time and often have side effects or lead to counter-reactions or remain unsuccessful, respectively.
Skin problems may have the most varying causes, such as damaging environmental influences (sun, air pollution), allergies, hormonal imbalance, bad eating habits, the taking of medicaments (antibiotics), wounds etc., and they occur more and more frequently. Many creams are aggressive, damage the sensitive skin parts and dehydrate them.
Varicose veins (primary or secondary varicosis) form on account of a mechanical impediment in the venous flow-back of blood and the peripheral venous pressure increased thereby, surface varices and deep varices with congestion phenomena forming. The causes therefor may be a slowed circulation (e.g. in case of longer confinement to bed), constitutionally caused as a consequence of a congenital connective tissue weakness or as a consequence of other vein diseases. For local treatment, in most instances creams, ointments, gels and the like are used which contain heparin. Heparin has an antithrombotic effect due to its function as a catalyst, by inhibiting the serine proteases in the coagulation cascade. Thereby, a series of blood coagulation factors are inactivated. Yet in case of a tendency to bleeding and in case of thrombocytopenias, heparin must not be used. Furthermore, it should not get into contact with open wounds, the eyes or the mucous membranes. Besides, counter-reactions may occur easily on account of an hypersensitivity to heparin.
It is thus the object of the present invention to provide an agent for topical application which has a broad application spectrum and thus may be employed for a plurality of uses, which, however, also is composed of complex components which are as close to natural as possible, and thus is well tolerable without any negative side effects. A further object of the present invention consists in providing a completely new, natural and effective agent for treating hemorrhoidal diseases. A further object of the present invention consists in providing an agent against loss of hair. Still another object of the present invention is the provision of a topically usable agent for treating skin problems, such as e.g., wrinkle formation, acne, impure skin, sun burn, wounds etc., as well as an agent for fighting varicose veins.
According to the invention, these objects are achieved by the use of a substance mixture comprising honey and olive oil for preparing a medicament for topical application. With the use according to the invention, the per se known healing effects of honey and olive oil can be utilized, the therapeutical effects being increased in the topical application in synergistic manner.
By application on the skin to be treated, the ingredients can unfold their effect directly at the desired site and can quickly lead to a sure healing success. By the fact that the substance mixture according to the invention contains purely natural substances, the application is without contraindications and adverse side-effects, in contrast to synthetically produced medicaments which frequently contain chemically produced substances in unnaturally high concentrations and of which the use is not without risks.
In this instance, the treatment is based on the action of purely natural substances, whereby the risk of counter-reactions of any type, e.g. allergies, hypersensitivity to ingredients and the like, is greatly reduced. Furthermore, the hemorrhoidal disease is to be healed quickly by aid of the substance mixture according to the invention, and not merely alleviated, as is frequently the case with the present medicaments.
Although honey and olive oil alone or in the form of substance mixtures together with other substances are already known in the medical science, yet so far a mixture of honey and olive oil has never been used in topical treatment.
Because of its various and extensive healing and alleviating effects, honey has been used in the art of healing for many centuries.
There is a large variety of different types of honey which, depending on their ingredients, have different properties as regards their application in the medical field. The main component of honey is invert sugar, further sugars are cane sugar, maltose, and, depending on the plant species visited, more rarely occurring sugars originating from the latter. Besides, sugar, honey contains further enzymes, such as invertase, diastases, catalase, amylase, phosphatase, glucose oxidase, which, with the cooperation of the oxygen of air, convert dextrose into gluconic acid and hydrogen peroxide. The latter provides oxygen in an extremely reactive form which in turn is an excellent germ killer and preservative. One of the most important components of honey is pollen. Of the organic acids, malic acid, succinic acid, gluconic acid, acidic acid, formic acid, of the inorganic acids phosphoric acid and hydrochloric acid are present. Honey furthermore contains mineral substances in a portion of up to 3%, among them Fe, Cu, P, S, K, Na, Mg, Ca, Si, Mn, Cl, Zn and, in small amounts, also vitamins (B
1
, B
2
, B
6
, pantothenic acid, nicotinic acid, H, folic acid and little vitamin C) and, in very small amounts, nearly all the amino acids. Furthermore, hormones, acetyl choline, which is involved in the conduction of nerve impulses, inhibines (bactericides) and vegetable dyes, such as flavones or carotines, and aromatic substances (alcohols, aldehydes, ketones and essential oils) have been found (“Doktor Biene, Bienenprodukte—ihre Heilkraft und Anwendung” by Paul Uccusic, pp. 45-53, 2nd Edition, 1987, Wilhelm Heyne Verlag, Munich).
Honeydew honeys are rich in resins and essential oils and thus are considerated for all diseases of the respiratory tract (bronchial catarrhs, but also as a supporting treatment of pulmonary tuberculosis and pneumonia), of the urogenital system (cystitis, urethriotis, prostatitis) and as a diuretic. Furthermore, a favorable effect can be found in case of gravel and renal calculi. Furthermore, a regulating effect has been postulated in case of problems of the portal circulation (hemorrhoids, congestion of the portal vein, inclination to venous thromboses). Honeys of mixed blossoms have a very favorable effect on allergic persons. Linden honey is sedating and antiseptic. Melissa honey is spasmolytic and sedating. Chest
Fulbright & Jaworski L.L.P.
Srivastava Kailash C.
Tate Christopher R.
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