Substance-containing carbon nanohorn composite having...

Drug – bio-affecting and body treating compositions – Designated inorganic nonactive ingredient or elemental...

Reexamination Certificate

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C424S489000, C514S579000, C514S663000, C514S673000, C977S734000, C977S736000, C977S740000, C977S744000, C977S748000, C977S750000

Reexamination Certificate

active

08084505

ABSTRACT:
The present invention provides: a carbon nanohorn composite including a carbon nanohorn, a substance encapsulated in the carbon nanohorn, and a polyamine adsorbed by chemical reaction firmly to a surface functional group present on the opening part on the surface of the carbon nanohorn, wherein the release amount and release rate of the encapsulated substance can be controlled using the difference in size, substituent or three-dimensional structure of the polyamine, which is used as a plug; a method of controlling the release of the encapsulated substance; and a process for producing the carbon nanohorn composite. The release amount and release rate of the substance encapsulated in the carbon nanohorn composite is controlled by selecting a polyamine molecule, which plugs the opening part formed in the carbon nanohorn by oxidation, by its size, substituent or three-dimensional structure.

REFERENCES:
patent: 2002-326032 (2002-11-01), None
patent: 2004-016909 (2004-01-01), None
patent: 2005-343885 (2005-12-01), None
patent: 2006-028421 (2006-02-01), None
patent: WO-2007/004545 (2007-01-01), None
patent: WO-2007/078007 (2007-07-01), None
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Lippert (Cisplatin: chemistry and biochemistry of a leading anticancer drug 1999, Helvetica Chimica Acta pp. 224-226 in part: 4 pages).
Ryota Yuge et al.; “Release-control of C60by polyamine-plugs on nanohorn holes”; The Fullerenes and Nanotubes Research Society, Jul. 12, 2006, (IP-37), p. 95.
Masako Yudasaka, et al.: “Carbon Nanotube to Carbon Nanohorn no DDS Oyo”; Pharm Tech Japan, Special extra issue, Oct. 28, 2005, vol. 21, No. 12, pp. 176 to 180.
Tatsuya Murakami, et al.:“Drug-Loaded Carbon Nanohorns: Adsorption and Release of Dexamethasone in Vitro”; Molecular Pharmaceutics, 2004, vol. 1, No. 6, pp. 399-405.
Ayaka Hashimoto, et al.: “Selective deposition of a gadolinium(II) cluster in a hole opening of single-wall carbon nanohorn”; PNAS (Proc. Nat. Acad.Sic), Jun. 8, 2004, vol. 101, No. 23, pp. 8527-8530.

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