Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-07-29
2010-02-02
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S007200, C435S091100, C536S024300, C536S024330
Reexamination Certificate
active
07655400
ABSTRACT:
The purpose of the present invention is to provide a substance having a several ten to several hundred-fold exchange reaction accelerating activity as compared with that of conventional copolymers. In particular, the invention provides a preparation for accelerating an exchange reaction between a nucleotide sequence at specific site of a double stranded DNA or RNA for its homologous nucleotide sequence, the preparation comprising a cationic polymer having a guanidine group-containing main chain and a hydrophilic functional groups as an active ingredient. Thus, a substance having a several ten to several hundred-fold exchange reaction accelerating activity as compared with that of conventional copolymers can be provided. With this substance, the nucleotide chain exchange can be performed at a lower temperature and/or a higher rate than in the prior art.
REFERENCES:
patent: 2001-78769 (2001-03-01), None
Aki Sakurai et al.; DNA-sa Kokan Hanno ni Okeru Jinko Kakusan Chaperone no Kino Hyoka; Polymer preprints, Japan, 2003, vol. 52, No. 13, pp. 3722-3723.
Won Jong Kim; Comb-Type Cationic Copolymer Expedites DNA Strand Exchange while Stabilizing DNA Duplex; Chem. Eur. J., 2001, vol. 7, No. 1, pp. 176-180.
Won Jong Kim; DNA Strand Exchange Stimulated by Spontaneous Complex Formation With Cationic Comb-Type Copolymer, J. Am. Chem. Soc., , 2002, vol. 124, No. 43, pp. 12676-12677.
Kaori Tajima et al.; Simple Basic Peptides Activate DNA Strand Exchange; Chemistry Letters, 2003, vol. 32, No. 5, pp. 470-471.
Kaori Tajima et al.; Acceleration of DNA strand exchange reaction by cationic polymers; Nucleic Acids Research Suppl., 2002, vol. 2, pp. 265-266.
Anwarul Ferdous et al.; Mechanism of Intermolecular Purine-Purine-Pyrimidine Triple Helix Stabilization by Comb-Type Polylysine Graft Copolymer at Physiologic Potassium Concentration, Bioconjugate Chem. 2000, No. 11, pp. 520-526.
Birch, Stewart, Kolasch & Birch. LLP
Japan Science and Technology Agency
Riley Jezia
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