Submicron emulsions for delivery of peptides

Details Submicron emulsions for delivery of peptides Submicron emulsions for delivery of peptides

1993-08-13

1996-05-07

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 8, 514 11, 514 12, 514 13, 514 14, 514 15, 514 18, 514 19, 424 7808, 424 7831, 424 7833, A01N 3718, A61K 3174, A61K 3816, A61K 3800

Patent

active

055146708

ABSTRACT:
The present invention provides emulsions comprising a plurality of submicron particles, a bioactive peptide, and an aqueous continuous phase or that effect enhanced oral bioavailability of the peptide. Another aspect of the invention provides compositions and methods of administering peptides in an emulsion comprising a plurality of submicron particles, a mucoadhesive macromolecule, a bioactive peptide, and an aqueous continuous phase, which promotes absorption of the bioactive peptide through mucosal surfaces by achieving mucoadhesion of the emulsion particles. Mucous surfaces suitable for application of the emulsions of the present invention may include corneal, conjunctival, buccal, sublingual, nasal, vaginal, pulmonary, stomachic, intestinal, and rectal routes of administration.

REFERENCES:
patent: 3919411 (1975-11-01), Glass et al.
patent: 4548922 (1985-11-01), Carey et al.
patent: 5055303 (1991-10-01), Riley, Jr.
patent: 5120710 (1992-06-01), Liedtke
patent: 5188837 (1993-02-01), Domb
patent: 5206219 (1993-04-01), Desai
J. Pharm. Pharmacol, 1992, 44 (Suppl. 1): 186-190, "Delivery Systems for Biopharmaceuticals", by S. S. Davis.
Meth Find Exp Clin Pharmacol. 1991, 13(3): 205-220, "Microemulsions for Improved Peptide Absorption from the Gastrointestinal Tract", by W. A. Ritschel.
The United States Pharmacopeia, The National Formulary, XXth Edition 1990, pp. 1910-1912.
Deutscher, Guide to Protein Purificaiton, Academic Press, 1990 pp. 77-78.

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