Submicron emulsions as ocular drug delivery vehicles

Details Submicron emulsions as ocular drug delivery vehicles Submicron emulsions as ocular drug delivery vehicles

1993-01-05

1996-03-05

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 75, 514 76, 514546, 514547, 514560, 514912, A61K 31685, A61K 3166, A61K 3122, A61K 31225

Patent

active

054968119

ABSTRACT:
An ocular drug delivery vehicle of an oil-in-water submicron emulsion comprising about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a non-ionic surfactant and an aqueous component, with the mean droplet size being in the submicron range, i.e., below about 0.5 .mu.m and preferably between about 0.1 and 0.3 .mu.m. Also, topical pharmaceutical compositions containing a drug such as an anti-glaucoma drug, beta adrenergic blocker or other autonomic system drug, a local anesthetic, a steroid, a non-steroidal anti-inflammatory drug, an antibiotic drug, an antifungal drug, an antiviral drug or combinations thereof and the vehicle described above. Methods of administering such vehicles or compositions to the eye of a patient while reducing irritation thereof and providing increased bioavailability of the drug.

REFERENCES:
patent: 4289080 (1981-09-01), Penley
patent: 4914088 (1990-04-01), Glonek et al.
Hardberger, R., "Effects of Drug Vehicles on Ocular Contact Time", 93:42-45 (1975).

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