Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Hemic or immune system
Reexamination Certificate
2002-07-08
2004-05-11
Patten, Patricia (Department: 1654)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Hemic or immune system
C424S435000, C424S520000, C424S562000, C424S577000, C424S578000, C514S002600, C514S012200, C530S399000, C530S837000
Reexamination Certificate
active
06733791
ABSTRACT:
FIELD OF THE INVENTION
The present invention is generally directed to methods and compositions that allow for sublingual administration of peptides that are stable at room temperature. Said sublingual compositions are in liquid and sublingual tablet format.
BACKGROUND OF THE INVENTION
The ability to administer peptides orally and have them absorbed efficiently has been a long-standing problem. Peptides are very susceptible to acid hydrolysis in the gut. The hydrolysis of any given peptide typically eliminates its physiological efficacy.
Therefore, there exists a clear need in the art for methods and compositions that will facilitate the oral administration and absorption of peptides without subjecting them to acid hydrolysis.
The prior art discloses oral administration of peptides. However, these peptides travel to the gut for absorption by the stomach lining, thereby exposing the peptides to acid hydrolysis. The prior art also describes the sublingual administration of medicaments, such as vasodilating agents (these sublingual vasodilating agents are intended for systemic treatments such as heart problems and the like). However, the prior art does not disclose the sublingual absorption of peptides nor the use of vasodilators to assist in the sublingual absorption of vasodilators.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide new and improved methods and compositions for the oral delivery of peptides to animals, preferably warm-blooded mammals, such as humans, pets and the like. The compositions provided herein may be produced in both tablet and liquid forms and are administered sublingually. The compositions comprise a room temperature stable peptide or complex of peptides that may be administered in a dosage of between 0.0001 mg/ml or gm and 600 mg/ml or gm.
It is another object of the present invention to provide a liquid composition that comprises a given peptide mixed in a mostly anhydrous medium, preferably comprising glycerin, a non-volatile water soluble solvent such as propylene glycol or one of the polyethylene glycols, and a topically effective vasodilator. The vasodilator can be methyl nicotinate, khellin, nitroglycerin, a calcium antagonist such as nifedipine, and the like. The addition of a different vasodilator, other than those noted above, does not change or alter the spirit of the invention. A surfactant, such as polysorbate 20, 60, or 80, may also be added to enhance absorption. Clearly, many other surfactants may be used in varying concentration without altering the spirit of the invention.
In the solid or liquid sublingual composition, a given peptide is mixed with an appropriate non-volatile water soluble solvent and a solid yet water soluble carrier such as lactose, sucrose, mannitol, and the like. Many other carriers and solvents can be used without altering the spirit of the invention. Solvents include, but are not limited to, propylene glycol, the polyethylene glycols, and the like. In addition, an appropriate vasodilator is added to the composition so as to increase vascular activity and thereby absorption by the sublingual mucous membranes of warm blooded mammals. As noted above, a surfactant, such as polysorbate 20, 60, or 80, may be used to enhance absorption. Clearly, many other surfactants may be used in varying concentration without altering the spirit of the invention.
The novel features that are considered characteristic of the invention are set forth with particularity in the appended claims. The invention itself, however, both as to its structure and its operation together with the additional object and advantages thereof will best be understood from the following description of the preferred embodiment of the present invention when read in conjunction with the accompanying drawings. Unless specifically noted, it is intended that the words and phrases in the specification and claims be given the ordinary and accustomed meaning to those of ordinary skill in the applicable art or arts. If any other meaning is intended, the specification will specifically state that a special meaning is being applied to a word or phrase. Likewise, the use of the words “function” or “means” in the Description of Preferred Embodiments is not intended to indicate a desire to invoke the special provision of 35 U.S.C. §112, paragraph 6 to define the invention. To the contrary, if the provisions of 35 U.S.C. §112, paragraph 6, are sought to be invoked to define the invention(s), the claims will specifically state the phrases “means for” or “step for” and a function, without also reciting in such phrases any structure, material, or act in support of the function. Even when the claims recite a “means for” or “step for” performing a function, if they also recite any structure, material or acts in support of that means of step, then the intention is not to invoke the provisions of 35 U.S.C. §112, paragraph 6. Moreover, even if the provisions of 35 U.S.C. §112, paragraph 6, are invoked to define the inventions, it is intended that the inventions not be limited only to the specific structure, material or acts that are described in the preferred embodiments, but in addition, include any and all structures, materials or acts that perform the claimed function, along with any and all known or later-developed equivalent structures, materials or acts for performing the claimed function.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention is a composition for the sublingual application of medicaments and the like, and methods thereof.
A liquid preparation containing a peptide with enhanced properties for the absorption of the sublingual mucosa of a warm-blooded mammal can be made a variety of different ways. Although many specific details associated with certain aspects of the invention are set forth below, those skilled in the art of pharmaceutical manufacture and specifically those skilled in the art of drug delivery will recognize that the present invention may have additional embodiments or that the invention may be practiced without several of the details disclosed herein.
A representative liquid formulation can be described utilizing thymosin fraction 5 as the peptide. Thymosin fraction 5 is a complex of thymic peptides that is stable at room temperature. The individual component peptides each have a molecular weight of less then 20,000 daltons.
EXAMPLE I
gm/%
Range %
1. Thymic Fraction 5
5.0
0.001-55
2. Glycerin
44.5
0.001-99
3. Propylene glycol
44.9
0.001-99
4. Methyl nicotinate
0.1
0.00001-25
5. Water
50
0-99
6. Polysorbate 80
0.5
0.0001-25
This composition may then be administered to a warm-blooded mammal until the desired dosage is achieved. The methyl nicotinate, by increasing local (topical) blood flow, enhances absorption of the peptides contained in said composition.
Alternatively, a given peptide may be administered in a stable tablet formulation as a sublingual preparation to a warm-blooded mammal. A representative solid formulation administered sublingually in tablet form can be described utilizing thymosin fraction 5 as the peptide. As noted previously, thymosin fraction 5 is a complex of peptides that is stable at room temperature. The individual component peptides each have a molecular weight of less than 20,000 daltons.
EXAMPLE 2
gm/%
Range %
1. Thymosin fraction 5
5.0
0.0001-70
2. Water
5.0
0-25
3. Sucrose/Lactose
69.5
25-99
4. Propylene glycol
0.5
0.0001-50
5. Silicon Dioxide
15.0
0-70
6. Methyl nicotinate
0.5
0.00001-25
The wetted mixture is formed into tablets of a desired weight. Said tablets are then dried at 30° C. for 36 hrs.
In use, the liquid composition or tablet composition is administered under the tongue of a warm-blooded mammal at the appropriately desired dosage.
Mann Maria A.
Mann Morris A.
Mann Maria A.
Patten Patricia
The Halvorson Law Firm
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