Subdermal biocompatible implants

Details Subdermal biocompatible implants Subdermal biocompatible implants

1990-10-31

1994-08-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424424, 424474, 424482, 424489, A61F 202, A61K 928, A61K 932, A61K 914

Patent

active

053426223

ABSTRACT:
The present invention provides pharmaceutical or veterinary implants which, when subdermally administered releases a peptide or protein in a substantially continuous manner. The implant includes the peptide or protein and an excipient encased within a polymeric coating which is permeable, swellable and, at normal physiological pH, is non-rupturing, non-dissolving and does not degrade over the useful life the implant. The coating forms a release rate limiting barrier. All of the components used to make the implant are of a biocompatible nature. The implant is particularly useful for the sustained release of proteins or peptides for regulating the hormonally controlled reproductive cycle in sheep.

REFERENCES:
patent: 3830907 (1974-08-01), Short et al.
patent: 4539199 (1985-09-01), Orban et al.
patent: 4666704 (1987-05-01), Shalati et al.
patent: 4765980 (1988-08-01), Deprince et al.
patent: 4784858 (1988-11-01), Ventouras
"Coating of Tablets and Small Particles with Acrylic Resins by Fluid Bed Technology", International Journal of Pharmaceutical Technology & Product Manufacture, vol. 2, No. 4, Dec. 1981, pp. 31-42.

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