Subcutaneous implants containing a degradation-resistant...

Details Subcutaneous implants containing a degradation-resistant... Subcutaneous implants containing a degradation-resistant...

2007-03-20

2011-12-27

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019400, C514S019500, C514S772300, C424S426000

Reexamination Certificate

active

08084427

ABSTRACT:
The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a degradation-resistant polylactide suitable for the preparation of subcutaneous implants. Sterilization of the polylactide via gamma-radiation as well as temperature stress result in a negligible decomposition of less than 1000 Dalton.

REFERENCES:
patent: 2005/0238618 (2005-10-01), Huang
patent: 0058481 (1982-08-01), None
patent: WO 93/24150 (1993-12-01), None
patent: WO 98/09613 (1998-03-01), None
patent: WO 03/022297 (2003-03-01), None
Nuutinen et al. (“Effect of gamma, ethylene oxide, electron beam, and plasma sterilization on the behaviour of SR-PLLA in vitro,” J. Biomat. Sci. Polymer Edn. (2002) 13 1325-1326).
Soriano et al. (“Biodegradable implantable fluconazole delivery rods designed for the treatment of fungal osteomyelitis: Influence of gamma sterilization,” J. Biomed Materials Research Part A, (2006) 77 632-638).
Horá{hacek over (c)}ek et al. (“Influence of Molecular Weight on the Resistance of Polylactide Fibers by Radiation Sterilization,” J. Applied Polymer Sci (1993) 50 1-5).
Edlund et al. (“Degradable Polymer Microspheres for Controlled Drug Delivery,” Adv in Polymer Sci (2002) 157 67-112).
PCT International Search Report—(PCT/EP2007/002447) Date of Mailing Jan. 30, 2008.
Nugroho et al., “Degradation of poly(L-lactic acid) by γ-irradiation”,Polymer Degradation and Stability, 2001, vol. 72, pp. 337-343.
Abstract of CN 1200032A, published on Nov. 25, 1998 and the English abstract from the PCT counterpart.

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