Subcutaneous glucose electrode

Details Subcutaneous glucose electrode Subcutaneous glucose electrode

1999-01-12

1999-10-12

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving glucose or galactose

435 4, 435 25, 435 28, 435 24, 435817, 435962, C12Q 154, C12Q 100, C12Q 126

Patent

active

059653809

ABSTRACT:
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

REFERENCES:
patent: 5356786 (1994-10-01), Heller et al.
patent: 5593852 (1997-01-01), Heller et al.

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