Styryl-substituted monocyclic and bicyclic heteroaryl compounds

Details Styryl-substituted monocyclic and bicyclic heteroaryl compounds Styryl-substituted monocyclic and bicyclic heteroaryl compounds

1994-03-17

1995-05-23

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546286, 546288, 546289, 546297, 546298, 546299, 546300, 546307, 546308, 546309, 546310, 546311, 546312, 546314, 546315, 546318, 546322, 546330, 514344, 514349, 514350, 514351, 514354, 514355, 514356, C07D21357, A61K 3144

Patent

active

054182450

ABSTRACT:
Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, said compound optionally substituted or polysubstituted, with the proviso that when said ring is polysubstituted, the substituents do not have a common point of attachment to said ring, and those compounds wherein no substituent on the heteroaryl group is a carboxy group or an ester group, and pharmaceutical compositions comprising such compounds.

REFERENCES:
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patent: 3337567 (1967-08-01), Walker et al.
patent: 3337568 (1967-08-01), Bencze et al.
patent: 4600712 (1986-07-01), Haken et al.
patent: 4678793 (1987-07-01), Klaus et al.
patent: 4826984 (1989-05-01), Berlin et al.
patent: 5196158 (1965-07-01), Bencze
Horner et al., Liebigs Ann. Chem, pp. 1183-1210, 1982.
Robinson et al, Tetrahedron, vol. 45, No. 13, pp. 4103-4112, 1989.

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