Study of polymer molecules and conformations with a nanopore

Details Study of polymer molecules and conformations with a nanopore Study of polymer molecules and conformations with a nanopore

2004-08-16

2010-12-07

Griffin, Walter D (Department: 1797)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Reexamination Certificate

active

07846738

ABSTRACT:
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

REFERENCES:
patent: 3815024 (1974-06-01), Bean et al.
patent: 3856633 (1974-12-01), Fletcher, III.
patent: 4456522 (1984-06-01), Blackburn
patent: 4521729 (1985-06-01), Kiesewetter et al.
patent: H201 (1987-01-01), Yager
patent: 4661235 (1987-04-01), Krull et al.
patent: 4874499 (1989-10-01), Smith et al.
patent: 4926114 (1990-05-01), Doutre
patent: 5001048 (1991-03-01), Taylor et al.
patent: 5111221 (1992-05-01), Fare et al.
patent: 5221447 (1993-06-01), Hjerten
patent: 5234566 (1993-08-01), Osman et al.
patent: 5356776 (1994-10-01), Kambara et al.
patent: 5376878 (1994-12-01), Fisher
patent: 5378342 (1995-01-01), Ikematsu et al.
patent: 5503744 (1996-04-01), Ikematsu et al.
patent: 5612179 (1997-03-01), Simons
patent: 5795782 (1998-08-01), Church et al.
patent: 5833826 (1998-11-01), Nordman
patent: 5911871 (1999-06-01), Preiss et al.
patent: 6015714 (2000-01-01), Baldarelli et al.
patent: 6054035 (2000-04-01), Kambara
patent: 6156502 (2000-12-01), Beattie
patent: 6190865 (2001-02-01), Jendrisak et al.
patent: 6203993 (2001-03-01), Shuber et al.
patent: 6210896 (2001-04-01), Chan
patent: 6214545 (2001-04-01), Dong et al.
patent: 6221603 (2001-04-01), Mahtani
patent: 6221635 (2001-04-01), Rovera et al.
patent: 6238866 (2001-05-01), Yeh et al.
patent: 6263286 (2001-07-01), Gilmanshin et al.
patent: 6267872 (2001-07-01), Akeson et al.
patent: 6355420 (2002-03-01), Chan et al.
patent: 6362002 (2002-03-01), Denison et al.
patent: 6403311 (2002-06-01), Chan et al.
patent: 6428959 (2002-08-01), Deamer
patent: 6464842 (2002-10-01), Golovchenko et al.
patent: 6503409 (2003-01-01), Fleming
patent: 6528258 (2003-03-01), Russell
patent: 6627067 (2003-09-01), Branton et al.
patent: 6673615 (2004-01-01), Denison et al.
patent: 6746594 (2004-06-01), Akeson et al.
patent: 6783643 (2004-08-01), Golovchenko et al.
patent: 7189503 (2007-03-01), Akeson et al.
patent: 7238485 (2007-07-01), Akeson et al.
patent: 7468271 (2008-12-01), Golovchenko et al.
patent: 7625706 (2009-12-01), Akeson et al.
patent: 2002/0039737 (2002-04-01), Chan et al.
patent: 2002/0081744 (2002-06-01), Chan et al.
patent: 2002/0119455 (2002-08-01), Chan et al.
patent: 2003/0044816 (2003-03-01), Denison et al.
patent: 2003/0059822 (2003-03-01), Chan et al.
patent: 2003/0066749 (2003-04-01), Golovchenko et al.
patent: 2003/0104428 (2003-06-01), Branton et al.
patent: 2004/0110205 (2004-06-01), Wang
patent: 2005/0053961 (2005-03-01), Akeson et al.
patent: 2005/0241933 (2005-11-01), Branton et al.
patent: 2006/0057585 (2006-03-01), McAllister
patent: 2006/0063171 (2006-03-01), Akeson et al.
patent: 2007/0054276 (2007-03-01), Sampson
patent: 2007/0190542 (2007-08-01), Ling et al.
patent: 2007/0194225 (2007-08-01), Zorn
patent: 2007/0281329 (2007-12-01), Akeson et al.
patent: 2008/0102504 (2008-05-01), Akeson et al.
patent: 2010/0028681 (2010-02-01), Dai et al.
patent: 30 28 569 (1982-02-01), None
patent: 1 009 802 (2004-08-01), None
patent: 1 038 171 (2006-02-01), None
patent: 2 232 769 (1990-12-01), None
patent: WO 94/25862 (1994-11-01), None
patent: WO 98/35012 (1998-08-01), None
patent: WO 99/24823 (1999-05-01), None
patent: WO 00/09757 (2000-02-01), None
patent: WO 00/56937 (2000-09-01), None
patent: WO 00/78668 (2000-12-01), None
patent: WO 00/79257 (2000-12-01), None
patent: WO 01/18251 (2001-03-01), None
patent: WO 01/42782 (2001-06-01), None
patent: WO 01/59684 (2001-08-01), None
patent: WO 02/42496 (2002-05-01), None
patent: WO 03/000920 (2003-01-01), None
patent: WO 03/003446 (2003-01-01), None
patent: WO 2004/077503 (2004-09-01), None
Akeson et al., “Microsecond Time-Scale Discrimination among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments within Single RNA Molecules,”Biophys. J.77:3227-3233 (1999).
Auld et al., “A Neutral Amino Acid Change in Segment IIS4 Dramatically Alters the Gating Properties of the Voltage-Dependent Sodium Channel,”Proc. Natl. Acad. Sci. USA87:323-327 (1990).
Bensimon et al., “Alignment and Sensitive Detection of DNA by a Moving Interface,”Science265:2096-2098 (1994).
Benz et al., “Mechanism of Sugar Transport through the Sugar-Specific LamB Channel ofEscherichia coliOuter Membrane,”J. Membr. Biol.100:21-29 (1987).
Benz et al., “Pore Formation by LamB ofEscherichia coliin Lipid Bilayer Membranes,”J. Bacteriol. 165:978-986 (1986).
Bezrukov et al., “Counting Polymers Moving through a Single Ion Channel,”Nature370:279-281 (1994).
Boulain et al., “Mutagenesis by Random Linker Insertion into the LamB Gene ofEscherichia coliK12,”Mol. Gen. Genet.205:339-348 (1986).
Boulanger et al., “Characterization of Ion Channels Involved in the Penetration of Phage T4 DNA intoEscherichia coliCells,”J. Biol. Chem.263:9767-9775(1988).
Boulanger et al., “Ion Channels are Likely to be Involved in the Two Steps of Phage T5 DNA Penetration intoEscherichia coliCells,”J. Biol. Chem.267:3168-3172 (1992).
Boyd et al., “Determinants of Membrane Protein Topology,”Proc. Natl. Acad. Sci. USA84:8525-8529 (1987).
Branton et al., “Biochemical Sensors. Adapting to Nanoscale Events,”Nature398:660-661 (1999).
Charbit et al., “Permissive Sites and Topology of an Outer Membrane Protein with a Reporter Epitope,”J. Bacteriol.173:262-275(1991).
Dargent et al., “Effect of Point Mutations on the In-Vitro Pore Properties of Maltoporin, a Protein ofEscherichia coliOuter Membrane,”J. Mol. Biol.201:497-506 (1988).
Dargent et al., “Selectivity for Maltose and Maltodextrins of Maltoporin, a Pore-Forming Protein ofE. ColiOuter Membrane,”FEBS Lett.220:136-142 (1987).
Deamer et al., “Characterization of Nucleic Acids by Nanopore Analysis,”Acc. Chem. Res.35:817-825 (2002).
DeBlois et al., “Electrokinetic Measurements with Submicron Particles and Pores by the Resistive Pulse Technique,”J. Colloid Interface Sci.61:323-335 (1977).
Ehrmann et al., “Genetic Analysis of Membrane Protein Topology by a Sandwich Gene Fusion Approach,”Proc. Natl. Acad. Sci. USA87:7574-7578 (1990).
Ferenci et al., “Channel Architecture in Maltoporin: Dominance Studies with LamB Mutations Influencing Maltodextrin Binding Provide Evidence for Independent Selectivity Filters in Each Subunit,”J. Bacteriol.171:855-861 (1989).
Ghadiri et al., “Artificial Transmembrane Ion Channels from Self-Assembling Peptide Nanotubes,”Nature369:301-304 (1994).
Hall et al., “Alamethicin. A Rich Model for Channel Behavior,”Biophys. J.45:233-247 (1984).
Hamill et al., “Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches,”Pflügers Arch.391:85-100(1981).
Harrington et al.,“The F Pilus ofEscherichia coliAppears to Support Stable DNA Transfer in the Absence of Wall-to-Wall Contact between Cells,”J. Bacteriol.172:7263-7264 (1990).
Heinemann et al., “Open Channel Noise: IV. Estimation of Rapid Kinetics of Formamide Block in Gramicidin A Channels,”Biophys. J.54:757-764 (1988).
Heinemann et al., “Open Channel Noise: V. Fluctuating Barriers to Ion Entry in Gramicidin A Channels,”Biophys. J.57:499-514 (1990).
Henry et al., “Blockade of a Mitochondria Cationic Channel by an Addressing Peptide: An Electrophysiological Study,”J. Membr. Biol.112:139-147 (1989).
Hoshi et al., “Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation,”Science250:533-538(1990).
Hoshi et al., “Two Types of Inactivation

Affiliated with

Also associated with

Rating

Study of polymer molecules and conformations with a nanopore does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Study of polymer molecules and conformations with a nanopore, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Study of polymer molecules and conformations with a nanopore will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4173847