Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1990-02-14
1992-08-25
Frinks, Roanald
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
4332011, A61F 228, A61C 800
Patent
active
051415100
DESCRIPTION:
BRIEF SUMMARY
FIELD OF ART
The present invention relates to a structure of artificial bones for use in bone implantation or grafting, formed from calcium phosphate compounds. Particularly, it relates to an artificial bone structure for use in bone implantation or grafting, which can be applied at a bone position to which load or force is applied, and is useful in the medical fields especially in orthopaedics, plastics and oral surgery.
BACKGROUND OF THE ART
Compounds of calcium phosphate, including hydroxyapatite and tricalcium phosphate have the similar chemical properties to those of live bone and teeth in a living body or organism. The sintered body thereof has good bio-compatibility, and then, can be used as an alternative material used for artificial bone, bone aid and artificial roots, in form of a dense or porous body.
Such conventional calcium phosphate structure in dense body form can have enough strength necessary to support biologically dynamic movement, whereas there is not found new bone growth nor generation of bone tissue into the artificial dense bone structure. Further, generally, the adherent force to the living tissue where the artificial bones are inserted or implanted is dependent on the adhering force at the smooth interface thereof, and then it can not have the adherent function or force higher than that expected therefrom. On the other hand, a porous body of calcium phosphate compounds has somehow a limit of the dynamic strength, and then implantation of such porous body into a bone site of applied weight or load should be avoided, and sole use of the porous body should be avoided.
In order to enable sole use of an artificial bones at a bone site of applied mechanical load, it is necessary to provide a calcium phosphate compound to produce organization and structure having good bio-compatibility, and a method of compounding with organic or inorganic elastic material, and further to provide a material in use for compounding or integrating with the biological material. Such material, or porous ceramic material is disclosed in Japanese Patent Application No. 60-16879/1985.
DISCLOSURE OF INVENTION
The subject to be solved technologically by the present invention is the provision of the strong and tough structure of artificial bone produced from calcium phosphate compounds in which bone can be newly organized or grown into the bone structure, and then the artificial bone is well adhered to biological organism formation, and new bone organization can be well developed into the artificial bone.
Then, it is an object of the present invention to provide an artificial bone structure of calcium phosphate compounds which can evidence high mechanical strength when implanted in a bone tissue.
The inventive structure of artificial bone for use in implantation is provided for solving the above mentioned subject, and the present invention resides in a new structure of artificial bone for use in implantation or grafting of the bone, comprising a sintered body of calcium phosphate compounds: and hollowed minute tubes having diameters of 0.1 to 2.0 mm, and the major portions thereof extending along with a direction of Haversian canal extension, and producing two dimensional closely packed arrangements in said body against the surface vertical to said direction, and being arranged with separation, distances of 1.0 to 5.0 mm. Preferably, the internal structure of said sintered body has really spherical pores having diameters of 50 to 600 micrometers, and the porosity of said structure is preferably 0.5 to 40 percent.
Hereinafter, "calcium phosphate compounds" may include hydroxyapatite, tricalcium phosphate, tetracalcium phosphate, and further calcium phosphate compounds which can constitute the artificial bone.
SIMPLE DESCRIPTION OF DRAWINGS
FIGS. 1A and 1B illustrate schematically the representative structure of the inventive artificial bone for use in implanting or grafting bone, which can have high strength and toughness.
FIG. 2 illustrates schematically the sectional view of the inventive structure of t
REFERENCES:
patent: 4629464 (1986-12-01), Takata et al.
patent: 4654314 (1987-03-01), Takagi et al.
patent: 4960426 (1990-10-01), Atsumi
Iijima Tomohiko
Ito Kuniomi
Ohmamiuda Kouichi
Takagi Shigehide
Yano Hideo
Brown Laurence R.
Frinks Roanald
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