Structure-based hepatitis C virus drug design

Details Structure-based hepatitis C virus drug design Structure-based hepatitis C virus drug design

2001-07-03

2010-02-02

Clow, Lori A (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Chemical analysis

C702S019000, C424S204100, C435S235100, C436S501000

Reexamination Certificate

active

07657385

ABSTRACT:
The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of compounds which bind to CD81 and thus block the binding of HCV. Methods such as docking and de novodrug design can be used.

REFERENCES:
patent: WO 99/18198 (1999-04-01), None
IPER for WO 02/02632 (corresponding to PCT/IB01/01450), posted to ofi.epoline.org on Feb. 14, 2003.
Geschwend et al. Journal of Molecular Recognition (1996) vol. 9, pp. 175-186.
Higginbottom et al. Journal of Virology (Apr. 2000) vol. 74, No. 8, pp. 3642-3649.
PDB file 1G8Q (submitted by Kitadokoro et al. Nov. 20, 2000).
Kitadokoro et al. (EMBO J. (Jan. 2001) vol. 1-2, pp. 12-18).
Kuntz et al., “A Geometric Approach to Macromolecule-Ligand Interactions”J. Mol. Biol. 161:269-288, 1982.
Petracca et al., “Structure-Function Analysis of Hepatitis C Virus Envelope-CD81 Binding”J. Virology74(10):4824-4830, May 2000.
Pileri et al., “Binding of Hepatitis C Virus to CD81”Science282:938-941, Oct. 1998.
Bisceglie, “Hepatitis C-Virology and Future Antiviral Targets”American J. Medicine107(6B):45S-48S, Dec. 1999.
Kitakokoro et al., “Crystallization and Preliminary Crystallographic Studies on the Large Extracellular Domain of Human CD81, a Tetraspanin Receptor for Hepatitis C Virus”Acta Cryst. D57:156-158, 2001.
Lybrand et al., .“Ligand-Protein Docking and Rational Drug Design”Current Opinion in Structural Biology5:224-228, 1995.

Affiliated with

Also associated with

Rating

Structure-based hepatitis C virus drug design does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Structure-based hepatitis C virus drug design, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Structure-based hepatitis C virus drug design will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4227392