Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-05-31
1999-07-27
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Vector, per se
435419, 4351723, 536236, 536 241, 800295, 800298, C12N 1529, C12N 1582, A01H 500, A01H 400
Patent
active
059289376
ABSTRACT:
Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
REFERENCES:
patent: 5013659 (1991-05-01), Bedbrook et al.
Mosimann et al. (1996), "A critical assessment of comparative molecular modeling of tertiary structure of protein" Proteins: Structure, Function and Genetics, 23 (3):301-317.
Blundell et al. (1987), "Knowledge-based prediction of protein structures and design of novel molecule", Nature 326:347-352.
Hattori et al. (1992), "Multiple resistance to sulfonylureas and imidazolinones conferred by acetohydroxyacid synthase gene with separate mutations for selective resistance", Mol. Gen. Genet., 232:167-173.
Yadav et al. (1986), "Single amino acid substitutions in the enzyme acetolactate synthase confer resistance to the herbicide sulfometuron methyl" Pro. Natl. Acad. Sci. USA, 83:4418-4422.
Bernasconi et al. (1995), "A naturally occurring point mutation confers broad range tolerance to herbicides that target acetolactate synthase", J. Biol. Chem., 270:17381-17385.
Sathasivan et al. (1990), "Nucleotide sequence of a mutant acetolactate synthase gene from an imidazolinone-resistant Arabidopsis thaliana var. Columbia", Nucl. Acids Res., 18:2188.
Bernasconi et al., Journal of Biological Chemistry, 270:17381-17385, 1995.
Blundell et al., Nature, 326:347-352, 1987.
Hattori et al., Mol Gen Genet., 232:167-173, 1992.
Haughn et al., Mol Gen Genet., 204:430-434, 1986.
Mosimann et al., Proteins, 23:301-317, 1995.
Sathasiva et al., Nucleic Acids Research, 18:2188, 1990.
Stidham, Weed Science, 39:428-434, 1991.
Yadav et al., Proc. Nat'l. Acad. Sci., USA, 83:4418-4422, 1986.
Kakefuda Genichi
Kwagh Jae-Gyu
Ott Karl-Heinz
Stockton Gerald W.
American Cyanamid Company
Haas Thomas
Robinson Douglas W.
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