Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1997-02-05
2000-07-11
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
530327, 530328, 514 15, 514 16, A61K 3804, A61K 39395, C07K 706, C07K 1600
Patent
active
060874414
ABSTRACT:
Human melanoma cells bear antigens that are recognized by autologous CD8+ cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically.
REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
patent: 5554506 (1996-09-01), van der Bruggen et al.
patent: 5554724 (1996-09-01), Melief et al.
Min Ding et al., "Cloning and Analysis of MAGE-1-Related Genes," Biochemical and Biophysical Research Communications, vol. 22:1:549-555 (1994).
Pierre van der Bruggen et al., "A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3," Eur. J. Immunol., vol. 24:3038-3043 (1994).
C. De Smet et al., "Sequence and expression pattern of the human MAGE2 gene," Immunogenetics, vol. 39:121-129 (1994).
Jorg Ruppert et al., "Prominent Role of Secondary Anchor Residues in Peptide Binding to HLA-A2.1 Molecules," Cell, vol. 74:929-937 (1993).
Victor H. Engelhard, "Structure of Peptides Associated With Class I and Class II MHC Molecules," Annu. Rev. Immunol., vol. 12:181-207 (1994).
Pierre G. Coulie et al., "A New Gene Coding for a Differentiation Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas," J. Exp. Med., vol. 180:35-42 (1994).
Esteban Celis et al., "Induction of anti-tumor cytotoxic T lymphocytes in normal human using primary cultures and synthetic peptide epitopes," Proc. Natl. Acad. Sci. USA, vol. 91:2105-2109 (1994).
A. R. M. Townsend et al., "The Epitopes of Influenza Nucleoproteiin Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides," Cell, vol. 44:959-968 (1968).
P. J. Bjorkman et al., "The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens," Nature, vol. 329:512-518 (1987).
M. Hubank et al., "Identifying differences in mRNA expression by representational difference analysis of cDNA," Nucleic Acids Research, vol. 22:25:5640-5648 (1994).
Etienne De Plaen et al., "Structure, chromosomal localization, and expression of 12 genes of the MAGE family," Immunogenetics, vol. 40:360-369 (1994).
Gordon Ada, "Twenty Years Into the Saga of MHC-Restriction" -Immunology and Cell Biology, vol. 72:447-454, (1994).
Peter Cresswell, "Questions of Presentations," Nature, vol. 343:-595-594, (1990).
P. Van Der Bruggen, et al. "A Gene Encoding An Antigen Recognized-By Cytolytic T Lymphocytes On A Human Melanoma" Science, vol. 254:1643-1647 (1991).
B. Van den Eynde, et al. "Human Tumour Antigens Recognized By-T-Cells: Perspectives For New Cancer Vaccines," Antigen Processing and Presentation, vol. 23 (1995).
Ayyoub Maha
Gairin Jean Edouard
Mazarguil Honore
Monsarrat Bernard
Van den Eynde Benoit
Ludwig Institute for Cancer Research
Nutter Nathan M.
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