Structurally determined metallo-constructs and applications

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

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424 111, 424 165, 534 14, 530300, 530326, 530327, 530328, 530329, 530330, 530331, A61K 5100, A61M 3614

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active

060277114

ABSTRACT:
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry methods. The construct has a conformationally constrained global secondary structure obtained upon complexing with a metal ion. The peptide constructs are of the general formula:

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Hruby et al., (1990) Biochemical Journal, vol. 268, pp. 249-262, "Emerging approaches in the molecular design of receptor-selective peptide ligands: Conformational, topographical and dynamic considerations".

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