Structurally altered capsular polysaccharides produced by mutant

Details Structurally altered capsular polysaccharides produced by mutant Structurally altered capsular polysaccharides produced by mutant

1994-06-10

1995-07-11

Griffin, Ronald W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C12P 1904

Patent

active

054320666

ABSTRACT:
Structurally altered capsular polysaccharides are produced by mutant bacteria. These polysaccharides are isolated by selecting a wild type bacterial strain and a phage producing degradative enzymes that have substrate specificity for the capsular polysaccharides produced by the wild type bacteria. Phage-resistant mutants producing capsular polysaccharides are selected and the structurally altered capsular polysaccharide is isolated therefrom.

REFERENCES:
patent: 5330903 (1994-07-01), Kern et al.
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Dutton et al., Carbohydrate Research, vol. 103 (1982), pp. 107-128.
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"Rheologically Interesting Polysaccharides From Yeasts", by Gene R. Petersen et al., 1989, pp. 845-867.
"Structural Modification of Polysaccharides, A Biochemical-Genetic Approach", by Roger G. Kern and Gene R. Petersen, Dec. 1991, pp. 73-78.
"Experiments in Molecular Genetics", by Jeffrey H. Miller, 1972, pp. 121-129.

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