Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1985-07-10
1988-04-12
Hazel, Blondel
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4352402, 4352401, 4352404, 435320, 435253, 435243, 536 27, 424 85, C12N 120, C12N 1500, C07H 2104
Patent
active
047374624
ABSTRACT:
A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods for the production and use of the modified IFN-.beta. (IFN-.beta..sub.ser17) are also provided. The specific activity of IFN-.beta..sub.ser17 is found to be substantially the same as that of native IFN-.beta..
REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
Shepard, H. Michael, et al., Nature, vol. 294, pp. 563-565, (1981).
Taniguchi, T. et al., Gene, vol. 10, pp. 11-15 (1980).
Knight, E., Jr. et al., Journal of Interferon Research, (1982), vol. 2, No. 3, pp. 421-429.
Allen, G. et al., Nature (1981), 78(10) 6186-6190.
Rieger, R. et al., Glossary of Genetics and Cytogenetics, p. 381.
Taniguchi, T. et al., Nature, vol. 285, pp. 547-549 (1980).
Lathe, R. F., et al., Genetic Engineering, pp. 30-51.
Smith, M. and Gillam, S. Constructed Mutants Using Synthetic Oligodeoxyribonucleotides as Site-Specific Mutagens-Department of Biochemistry, Faculty of Medicine University of British Columbia.
Goeddel, D. V. et al., Nucleic Acids Research, vol. 8 No. 18, pp. 4059-4075.
Taniguchi, T. et al., Proc. Natl. Acad. Sci vol. 77, No. 9, pp. 5230-5233 (1980).
Allen, G. et al., Nature., vol. 287 (1980), pp. 408-411.
Levy, W. P., et al., Proc. Natl. Acad. Sci., vol. 78, No. 10, pp. 6186-6190 (1981).
Rastetter, W. H., Trends in Biotechnology, vol. 1, No. 3 (1983).
Goeddel, D. V., et al., Nature, vol. 287, pp. 411-416 (1980).
Derynck, R. et al., Nature vol. 287, pp. 193-197, (1980).
Derynck, R., et al., Nature vol. 285, pp. 542-546, (1980).
Stewart, A. G., et al., Nucleic Acids Research, vol. 8, pp. 1913-1931 (1980).
Lin Leo S.
Lu Shi-Da Yu
Mark David F.
Cetus Corporation
Halluin Albert P.
Hazel Blondel
Rajender Shyamala T.
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