Structural gene of pneumococcal protein

Details Structural gene of pneumococcal protein Structural gene of pneumococcal protein

1993-06-03

1995-12-19

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 237, 536 2433, C07H 2104

Patent

active

054769299

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

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