Strontium-substituted apatite coating

Stock material or miscellaneous articles – Hollow or container type article – Glass – ceramic – or sintered – fused – fired – or calcined metal...

Reexamination Certificate

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C428S035700, C428S036500, C424S422000, C424S602000, C606S076000, C623S011110, C623S023560, C623S023570

Reexamination Certificate

active

08067069

ABSTRACT:
An implantable article including a biocompatible substrate and a bioactive strontium-substituted calcium phosphate ceramic apatite coating chemically bonded to at least a portion of the surface of the biocompatible substrate, wherein the strontium-substituted calcium phosphate ceramic apatite coating includes nanopores, nanocrystals and strontium ions, and includes a hexagonal crystal structure of apatite having a molar ratio of strontium ions to calcium ions of about 0.0001 to about 0.5, and the strontium ions inhibit bone resorption in vitro and enhance bone formation in vivo so that the implantable article exhibits enhance fixation and bone ingrowth in and around the implantable article.

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