Stressed polymeric device for controlled release of a substance

Details Stressed polymeric device for controlled release of a substance Stressed polymeric device for controlled release of a substance

1986-10-30

1989-05-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424425, 424426, 424427, 424428, 424411, 424433, 424449, 424484, 424487, A61K 914, A61F 200

Patent

active

048308609

ABSTRACT:
A matrix device for controlled release of at least one active agent to an ambient environment, said matrix comprising an active agent--or agents--containing polymer which has been subjected to tensile stress. Included is a laminate device comprising at least one matrix as core sheet, said core sheet or sheets comprising the active agent or agents in a polymer matrix which has been subjected to stress and, in a further embodiment, a porosity enhancing agent in admixture with said agent; the core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. Also included are methods for making such a device.

REFERENCES:
patent: 3926188 (1975-12-01), Baker et al.
patent: 4102991 (1978-07-01), Kydonieus
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4228149 (1980-10-01), Brewer et al.
patent: 4321117 (1982-03-01), Kaetsu et al.
patent: 4601893 (1986-07-01), Cardinal
Rhine et al., "Controlled Release of Bioactive Materials", R. Baker, ed., Academic Press, pp. 177-187 (1980).

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