Stress-responsive activator of p300 (strap) protein

Details Stress-responsive activator of p300 (strap) protein Stress-responsive activator of p300 (strap) protein

2008-03-25

2008-03-25

Kaushal, Sumesh (Department: 1633)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C536S023500, C435S320100, C435S325000, C435S070100, C514S002600

Reexamination Certificate

active

10471573

ABSTRACT:
The invention provides a protein which is a stress-responsive activator of the p300 protein, and nucleic acid sequences encoding the protein. The protein performs a key role in facilitating stress-responsive protein-protein interactions within the p300 co-activator complex. The STRAP protein facilitates the interaction of other proteins in the p300 complex, and is thus a target for assays for modulators of the complex.

REFERENCES:
patent: WO 01/60860 (2001-08-01), None
Demonacos, C. et al ., “A TPR motif Cofactor Contributes to p300 Activity in the p53 Response”, Jul. 2001, Mol. Cell, vol. 8: pp. 71-84.
Ngo, J. et al. Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, 1994, The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 and 492-495.
Rudinger, J. “Characteristics of the amino acids as components of a peptide hormone sequence”, 1976, in Peptide Hormones, Parsons (ed.), University Park Press: Baltimore, MD, pp. 1-7.
Shikama, N. et al., “A Novel Cofactor for p300 that Regulates the p53 Response”, 1999, Mol. Cell, vol. 4: pp. 365-376.
Demonacos Constantinos et al; “Transcriptional Control During the p53 Response”; Cell Biology International, vol. 25, No. 2, 2001, pp. A3-A4, XP008007026.
Demonacos et al; “A TPR Motif Cofactor Contributes to p300Activity in the p53 Response”; Molecular Cell, (Jul. 2001) 8 (1) 71-84, Xp001074287.
Shikama Noriko et al; “A Novel Cofactor for p300 That Regulates the p53 Response”; Molecular Cell, vol. 4, No. 1999, pp. 365-376, XP002217510.
Database EMBL Online, Mar. 9, 2001, NIH-MGC Project: “Mus Musculus, mRNA, Partial cds”; Database Accession No. BC003272; Xp002217511.
Database Swissprotein Online, Mar. 4, 2002, Mao et al; “Human TPRs Structural Domain Protein SEQ NO: 2”; Database Accession No. ABB04616, XP002217512.
Database Geneseq Online, Mar. 4, 2002; Mao et al; “Human TPRs Structural Domain Encoding cDNA SEQ ID NO: 1”; Database Accession No. ABA04247, XP002217513.
Database Genseq Online, Nov. 6, 2001, Ota et al: “Human Polypeptide, SEQ ID NO: 3623”; Database Accession No. AAM93700, XP002217514.
Database Genseq Online, Nov. 6, 2001, Ota et al: “Human Full-Length cDNA, seq id no: 3522”; Database Accession No. AAK94644, XP002217515.
Database Genseq Online, Sep. 16, 2002, Schlegel et al; “Human Prostate Expression Marker cDNA 29199”; Database Accession No. ABV29208; XP002217517.
Database Genseq Online, Jul. 27, 2001, Williams et al; cDNA Library Derived SEQ 1039; Database Accession No. AAH31105, XP002217516.

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