Streptozotocin analogs

Details Streptozotocin analogs Streptozotocin analogs

1974-12-12

1976-02-24

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260211R, 424180, C07H 506, C07H 1502

Patent

active

039403831

ABSTRACT:
New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N.sub.2 O.sub.3 : 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose; methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside; methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside; methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.

REFERENCES:
patent: 3767640 (1973-10-01), Suami et al.

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