Streptoverticillium ferm P-10489 which produces antitumor agent

Details Streptoverticillium ferm P-10489 which produces antitumor agent Streptoverticillium ferm P-10489 which produces antitumor agent

1992-12-04

1994-03-01

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435118, 435119, 435121, 435127, 435128, 435908, C12P 1718, C12P 1716, C12P 1710

Patent

active

052906981

ABSTRACT:
A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism Streptoverticillium FERM P-10489, capable of producing the novel substance are disclosed.

REFERENCES:
T. Kaneko et al., "Two Synthetic Approaches to Rebeccamycin", Tetrahedron Letters, vol. 26, No. 34, pp. 4015-4018, (1985).
J. Bergman et al., "Synthesis of Indolo[2,3-a]pyrrolo[3,4-c]carbazoles by Double Fischer Indolizations", J. Org. Chem., vol. 54, pp. 824-828, (1989).
W. Steglich et al., "Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria Denudata", Angew. Chem. Int. Ed. Engl., vol. 19, No. 6, pp. 459-460, (1980).

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