Streptomyces microorganism useful for the preparation of (R)-bac

Details Streptomyces microorganism useful for the preparation of (R)-bac Streptomyces microorganism useful for the preparation of (R)-bac

1997-01-31

1998-12-01

Redding, David A.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435885, 435902, C07C 0000

Patent

active

058437657

ABSTRACT:
The invention disclosed relates to the biological production of substantially isomerically pure (R)-baclofen and structurally related compounds, from the racemic mixture of (R)- and (S)-isomers thereof, and to the isolation of a Streptomyces microorganism from Nature which is capable of preferentially metabolizing one of the isomers while showing minimal metabolic activity on the other isomer. A fermentation or bioconversion process using this microorganism or the cell-free enzymes derived therefrom for the biological resolution of a racemic mixture of (R)- and (S)-baclofen and structurally related compounds is also disclosed.

REFERENCES:
patent: 4204044 (1980-05-01), Suhara et al.
patent: 5108917 (1992-04-01), Bertola et al.
patent: 5302528 (1994-04-01), Battistel et al.

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