Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2011-08-30
2011-08-30
Kam, Chih-Min (Department: 1656)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S252300, C435S076000, C536S023200
Reexamination Certificate
active
08008078
ABSTRACT:
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures ofS. avermitilis. The present invention further relates to vectors, host cells, and mutant strains ofS. avermitilisin which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
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Chen Yan
Gustafsson Claes
Kim Seran
Krebber Anke
Minshull Jeremy S.
Kam Chih-Min
Misiak Paul M.
Pfizer Inc.
Pfizer Products Inc.
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