Streptomyces antibioticus ATCC 31771 and process for obtaining s

Details Streptomyces antibioticus ATCC 31771 and process for obtaining s Streptomyces antibioticus ATCC 31771 and process for obtaining s

1983-11-03

1985-12-24

Rosen, Sam

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435888, 435 74, 435 75, 435 76, C12R 148, C12N 120

Patent

active

045606625

ABSTRACT:
The fermentation of a substrate selected among erythronolide B, erythronolide A and erythronolide A oxime with a novel mutant, Streptomyces antibioticus ATCC 31771, obtained from an industrial stock for the production of oleandomycin, said novel mutant being incapable of producing the same oleandomycin, permits novel macrolide antibiotics to be produced, having not only an activity range like that of erythromycin, but characterized by a greater stability in acidic environment, whereby for the administration of the antibiotic it is no longer necessary to have recourse to esters and/or salts highly toxic for the organism.

REFERENCES:
patent: 3697547 (1972-10-01), Kurath
patent: 3855200 (1974-12-01), Krowicki et al.
patent: 3992264 (1976-11-01), Kierstead et al.
patent: 4152424 (1979-05-01), Kierstead et al.
Bolshakova, Chemical Abstracts, vol. 95, p. 218834; 1981; No. 218830d.
The Journal of Antibiotics (Jul. 1976) "A New Semisynthetic Macrolide Antibiotic 3-0-Olendrosyl-5-0-Desosaminylerthronolide A Oxime."

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