Streptolysin O antigen derivatives, their production and uses

Details Streptolysin O antigen derivatives, their production and uses Streptolysin O antigen derivatives, their production and uses

1994-08-26

1997-12-23

Russel, Jeffrey E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 693, 530350, 5303895, 530403, 530413, 530806, 530825, C07K 14315, C07K 1612, C12P 2102, G01N 3353

Patent

active

057006482

ABSTRACT:
This application teaches a cytolytic derivative of the thiol-activated protein streptolysin O. The derivatization comprises the deletion of the amino acid cysteine from the amino acid sequence of naturally occurring streptolysin O; end optionally other alterations in said naturally occurring amino acid sequence by amino acid substitution, deletion, inversion, insertion or addition.

REFERENCES:
patent: 4508831 (1985-04-01), Toth
patent: 4517303 (1985-05-01), Freytag et al.
patent: 5354846 (1994-10-01), Kehoe
Saunders, et al., Infection and Immunity 57, 2547 (Aug., 1989).
Pinkney et al., Infection and Immunity 57, 2553 (Aug., 1989).

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