Streptolysin O antigen derivatives, its production and uses

Details Streptolysin O antigen derivatives, its production and uses Streptolysin O antigen derivatives, its production and uses

1993-06-08

1994-10-11

Furman, Keith C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530806, 530413, 5303871, 436518, 436522, C07K 1504, C07K 318, C12Q 104

Patent

active

053548469

ABSTRACT:
A non-toxic and non-cytolytic derivative of streptolysin O which retains at least one (preferably immunodominant) epitope is produced, and can be used especially in diagnostic tests for detecting of the presence of antibodies to Streptococcus pyogenes in a sample.

REFERENCES:
patent: 4379850 (1983-04-01), Ricci
patent: 4629783 (1986-12-01), Cosand
Pomgor, S. 1987. Methods in Enzymology 154:450-473.
Creighton, T. E. Protein: Structures and Molecular Principles. (W. H. Freeman and Company, New York, 1983), pp. 93-99.
Lerner, R. A. 1982. Nature 299:592-596.
Kehoe et al. 1987,. Infection and Immmunity 55(12): 3228-3232.
Kehoe et al. 1984. Infection and Immunity 43(3): 804-810.

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