Streptokinase-coding recombinant vectors

Details Streptokinase-coding recombinant vectors Streptokinase-coding recombinant vectors

1984-03-02

1988-08-16

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 68, 435 70, 4351723, 435253, 435320, 536 27, 935 14, 935 29, C12N 120, C12N 700, C12N 970, C12N 1500, C07H 1512, C12P 2100, C12P 2102

Patent

active

047644699

ABSTRACT:
A recombinant vector adapted for transformation of a suitable bacterial microorganism host to produce and secrete streptokinase. The recombinant vector comprises a plasmid into which a polydeoxyribonucleotide fragment from Streptococcus equisimilis H46A which codes for streptokinase synthesis and secretion has been inserted. The transformant bacterial microorganism including this recombinant plasmid vector produces streptokinase suitable for clinical fibrinolytic usage after purification.

REFERENCES:
patent: 4532211 (1985-07-01), Sako et al.
Jackson et al., Biochemistry 21:6620-6625, 1982.
Jackson et al., In Methods in Erzymology, vol. 80: 387-394, 1981.

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