Streptococcus pneumoniae gene sequence FtsY

Details Streptococcus pneumoniae gene sequence FtsY Streptococcus pneumoniae gene sequence FtsY

1997-12-08

1999-09-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352523, 435471, 536 237, C12P 2106, C12N 120, C12N 1500, C07H 21044

Patent

active

059587300

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

REFERENCES:
Adrian Zelazny, et al. "The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide" Proc. Natl. Acad. Sci. 94:6025-6029 (Jun. 1997).
Ted Powers and Peter Walter. "Reciprocal Stimulation of GTP Hyrdolysis by Two Directly Interacting GTPases" Science 269:1422-1424 (Sep. 8, 1995).
Douglas M. Freymann, et al. "Structure of the conserved GTPase domain of the signal recognition particle" Nature 385:361-364 (Jan. 23, 1997).
Guillermo Montoya, et al. "Crystal structure of the NG domain from the signal-recognition particle receptor FtsY" Nature 385:365-368 (Jan. 23, 1997).
Nancy D. Ulbrandt, et al. "The E. Coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins" Cell 88:187-196 (Jan. 24, 1997).

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