Streptococcus pneumoniae gene sequence dnaG

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 697, 435 711, 435 41, 4352431, 4352521, 4352523, 4352534, 536 231, 536 232, 536 234, C12P 2106, C12P 2104, C12N 100, C12N 112

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061626171

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding dnaG of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

REFERENCES:
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Killu Tougu and Kenneth J. Marians. "The Extreme C Terminus of Primase Is Required for Interaction with DnaB at the Replication Fork." The Journal of Biological Chemistry 271(35):21391-21397 (Aug. 30, 1996).
Sungsub Kim, et al. ".tau.Couples the Leading- and Lagging-Strand Polymerases at the Escherichia coli DNA Replication Fork." The Journal of Biological Chemistry 271(35):21406-21412 (Aug. 30, 1996).
Markus Grompe, et al. "Mutati0ons in the Escherichia coli dnaG Gene Suggest Coupling between DNA Replication and Chromosome Partitioning." Journal of Bacteriology 173(3):1268-1278 (Feb. 1991).
Lee Rowen and Arthur Kornberg. "Primase, the dnaG Protein of Escherichia coli: An Enzyme which Starts DNA Chains" The Journal of Biological Chemistry 253(3):758-764 (Feb. 10, 1978).
Robert A. Britton, et al. "Characterization of Mutations Affecting the Escherichia coli Essential GTPase Era That Suppress Two Temperature-Sensitive dnaG Alleles." Journal of Bacteriology 179(14):4575-4582 (Jul. 1997).

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