Streptococcus pneumoniae antigens and vaccines

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...

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4241651, 4241841, 42419711, 4242001, 4242441, 435 72, 435 734, 435 36, 435 693, 4352523, 4352534, 435340, 4353884, 536 243, 536 2432, 536 253, A61K 3940, A61K 3900, A61K 39385, A61K 3902

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061594695

ABSTRACT:
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

REFERENCES:
Martin et al., The EMBO Journal, 11(11):3831-3836 (1992).
Altschul et al., J. Mol. Biol., 215:403-410 (1990).
Pearson et al., Proc. Natl. Acad. Sci., 85:2444-2448 (1988).

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