Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Reexamination Certificate
2006-05-16
2006-05-16
Graser, Jennifer E. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
C530S387100, C530S388100, C424S130100, C424S141100, C424S150100, C424S164100, C424S244100
Reexamination Certificate
active
07045132
ABSTRACT:
The invention provides a nucleic acid encoding the 37-kDa protein fromStreptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are antibodies which selectively binds the polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are vaccines comprising immunogenic polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Further provided is a method of detecting the presence ofStreptococcus pneumoniaein a sample comprising the steps of contacting a sample suspected of containingStreptococcus pneumoniaewith nucleic acid primers capable of hybridizing to a nucleic acid comprising a portion of the nucleic acid encoding the 37-kDa protein, amplifying the nucleic acid and detecting the presence of an amplification product, the presence of the amplification product indicating the presence ofStreptococcus pneumoniaein the sample. Further provided are methods of detecting the presence ofStreptococcus pneumoniaein a sample using antibodies or antigens, methods of preventing and treatingStreptococcus pneumoniaeinfection in a subject.
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Ades Edwin W.
Carlone George M.
Russell Harold
Sampson Jacquelyn
Tharpe Jean A.
Graser Jennifer E.
Needle & Rosenberg P.C.
The Government of the United States of America, as represented b
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