Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1999-03-31
2000-12-26
Navarro, Albert
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435193, 435212, 530350, C12N 900, C12N 910, C07K 100
Patent
active
061657603
ABSTRACT:
The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
REFERENCES:
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J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antiobiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 32-324 (1980).
Fraser et al., "The Minimal Gene Complement of Mycoplasma gentialium", Science, 270 p. 397-403 (1995).
Breton et al., Glutamyl-tRNA Synthetases of Bacillus subtilis 168T and of Bacillus stearothemopilus:, Journal of Biological Chemistry, 265(30) p. 18348-18255 (1990).
Brun et al., "Closely Spaced and Divergent Promoters for an Aminoacyl-tRNA Synthetase Gene and a tRNA Operon in Escherichia coli", Journal of Molecular Biology, 214 p. 845-864 (1990).
Jaworski Deborah D.
Lawlor Elizabeth J.
Wang Min
Deibert Thomas S.
Gimmi Edward R.
King William T.
Navarro Albert
SmithKline Beecham Corporation.
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