Streptococcal C5a peptidase vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4242341, A61K 3909, A61K 3902

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058465472

ABSTRACT:
Novel vaccines for use against .beta.-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against .beta.-hemolytic Streptococcus colonization or infection by administering such a vaccine.

REFERENCES:
patent: 4454121 (1984-06-01), Beachey et al.
patent: 4695562 (1987-09-01), Beachey et al.
patent: 4772584 (1988-09-01), Cleary et al.
patent: 5124153 (1992-06-01), Beachey et al.
patent: 5162226 (1992-11-01), Beachey et al.
Bronze, M., et al., "Epitopes of group A streptococcal M protein that envoke cross-protective local immune responses", J. Immunol., 148, 888-893.
Courtney, H. S., et al., "Analysis of the role of M24 Protein in group A Spreptococcal adhesion and colonization by use of `omega`-interposon mutagenesis", Infect. Immun., 62, 4868-4873, (1994).
Fischetti, V.A., et al., "Protection against streptoccal pharyngeal colonization with vaccines composed of M protein conserved regions", Plenum Press,, 159-167, (1991).
Fischetti, V.A. et al., "Protection against streptococcal pharyngeal colinization with a vacine: M protein recombinant", Science, 244, 1487, (1989).
Ji, Y. et al., "C5a peptidase alters clearance and trafficking of group A streptococci by infected mice", Infect. Immun., 64,, 503-510, (1996).
Ji, Y., et al., "Intranasal immunization with C5a peptidase prevents nasopharyngeal colonization of mice by the group A steptococcus", Infect. Immun., 65, 2080-2087, (1997).
Kapur, V., et al., "Vaccination with steptococcal extracellular cysteine protease (interleukin-1B convertase) protects mice against challenge with heterologous group A streptococci", Microbial. Path., 16, 443-450, (1994).
Medaglini, D., et al., "Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization", Proc. Natl. Acad. Sci. USA, 6868-6872, (1995).
Raeder, R., et al., "Properties of IgG-binding proteins expressed by Streptococcus pyogenes isolates are predictive of invasive potential", J. Infect. Dis., 173, 888-895, (1996).
Sriskandan, S., et al., "Streptococcal pyrogenic exotoxin A (SPEA) release, distribution, and role in a murine model of fasciitis and mult-organ failure due to Streptococcus pyogenes", J. Infect. Dis, 173, 1399-1407, (1996).
Sriskandan, S., et al., "The role of nitric oxide in experimental murine sepsis due to pyrogenic exetoxin A-producing Streptococcus pyogenes", Infect. Immun., 65, 1767-1762, (1997).
Vugia, D.J., et al., "Invasive group A streptococcal infections in children with varicella in Southern California", Pediatr. Infect. Dis. J., vol. 15, No. 2, 146-150, (1996).
Wessels, M., et al., "Critical role of the group A streptococcal capsule in pharyngeal colonization and infection in mice", Proc. Natl. Sci. USA, 91, 12238-12242, (1994).
D. Bessen et al., "Influence of Intranasal Immunization with Synthetic Peptides Corresponding to Conserved Epitopes of M Protein on Mucosal Colonization by Group A Streptococci", Infection and Immunity, 56, pp. 2666-2672, (Oct. 1988).
S. Booth et al., "Dapsone Suppresses Integrin-Mediated Neutrophil Adherence Function", The Journal of Investigative Dermatology, 98, pp. 135-140, (Feb. 1992).
M. Boyle et al., "Measurement of Leukocyte Chemotaxis In Vivo", Methods in Enzymology, 162, pp. 101-114, (1988).
M. Bronze et al., "Protective Immunity Evoked by Locally Administered Group A Streptococcal Vaccines in Mice", The Journal of Immunology, 141, pp. 2767-2770, (Oct. 1988).
E. Brummer et al., "Immunological Activation of Polymorphonuclear Neutrophils for Fungal Killing: Studies with Murines Cells and Blastomyces Dermatitidis In Vitro", Journal of Leukocyte Biology, 36, pp. 505-520, (1984).
C. Chen et al., "Complete Nucleotide Sequence of the Streptococcal C5a Peptidase Gene of Streptococcus Pyogenes", The Journal of Biological Chemistry, 265, pp. 3161-3167, (1990).
J. Clark et al., "A New Method for Quantitation of Cell-Mediated Immunity in the Mouse" Journal of the Reticuloendothelial Society, 25, pp. 255-267, (Mar. 1979).
P. Cleary et al., "Similarity Between the Group B and A Streptococcal C5a Peptidase Genes", Infection and Immunity, 60, pp. 4239-4244, (Oct. 1992).
P. Cleary et al., "Streptococcal C5a Peptidase is a Highly Specific Endopeptidase", Infection and Immunity, 60, pp. 5219-5223, (Dec. 1992).
P. Cleary et al., "A Streptococcal Inactivator of Chemotaxis: A new Virulence Factor Specific to Group A Streptococci", Recent Advances in Streptococci and Streptococcal Diseases, pp. 179-180. ( Y. Kimura, S. Kotami and Y Shiokawa (ed.); Reedbooks Ltd.; Berkshire, England; 1984.).
P. Cleary et al., "Virulent Human Strains for Group G Streptococci Express a C5a Peptidase Enzyme Similar to that Produced by Group A Streptococci", Infection and Immunity, 59, pp. 2305-2310, July 1991).
P. Fenderson et al., "Tropomyosin Shares immunologic Epitopes with Group A Streptococcal M Proteins", The Jounal of Immunology, 142, pp. 2475-2481, (Apr. 1989).
V. Fischetti, "Streptococcal M Protein: Molecular Design and Biological Behavior", Clinical Microbiology Reviews, 2, pp. 285-314 , (Jul. 1989).
H. Hill et al., "Group B Streptococci Inhibit the Chemotactic Activity of the Fifth Component of Complement", The Journal of Immunology, 141, pp. 3551-3556, (Nov. 1988).
R. Hope-Simpson, "Streptococcus Pyogenes in the Throat: A Study in a Small Population, 1962-1975", J. Hyg. Camb., 87, pp. 109-129, (1981).
U. Laemmli, "Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4", Nature, 277, pp 680-685, (Aug. 1970).
P. Lee et al., "Quantification and Toxicity of Group A Streptococcal Pryogenic Exotoxins in an Animal Model of Toxic Shock Syndrome-Like Illness", Journal of Clinical Microbiology, 27, pp. 1890-1892, (Aug. 1989).
T. Martin et al., "The Effect of Type-Specific Polysaccharide Capsule on the Clearance of Group B Streptococci from the Lungs of Infant and Adult Rats", The Journal of Infectious Diseases, 165, pp. 306-314, (Feb. 1992).
B. Massell et al., "Rheumatic Fever Following Streptococcal Vaccination", JAMA, 207, pp. 1115-1119, (Feb. 1969).
J. McGhee et al., "New Perspective in Mucosal Immunity with Emphasis on Vaccine Development", Seminars in Hematology, 30 , pp. 3-15, (Oct. 1993).
S. O'Connor et al., "The Human Antibody Response to Streptococcal C5a Peptidase", The Journal of Infectious Diseases, 163, pp. 109-116, (Jan. 1991).
S. O'Connor et al., "In Vivo Streptococcus Pyogenes C5a Pepidase Activity: Analysis Using Transposon-and Nitrosoguanidine-Induced Mutants", The Journal of Infectious Diseases, 156, pp. 495-504, (Sep. 1987).
A. Podbielski et al., "The Group A Streptococcal VirR49 Gene Controls Expression of Four Structural Vir Regulon Genes", Infection and Immunity, 63, pp. 9-20, (Jan. 1995).
T. Springer et al., "Mac-1: A Macrophage Differentiation Antigen Indentified by Monoclonal Antibody", European Journal of Immunology, 9, pp. 301-306, (1979).
D. Stevens, "Invasive Group A Streptococcus Infections", Clinical Infectious Diseases, 14, pp. 2-13, (Jan. 1992).
A. Suvorov et al., "C5a Peptidase Gene from Group B Streptococci", Genetics and Molecular Biology of Streptococci, Lactococci, and Enterococci, pp. 230-232. (G. Dunny, P. Cleary and L. McKay (ed.); American for Microbiology; Washington, D.C.; 1991).
D. Wexler et al., "Mechanism of Action of the Group A Streptococcal C5a Inactivator", Proc. Natl. Acad. Sci., 82, pp. 8144-8148, (Dec. 1985).
Berge et al The Journal of Biological Chem 270:9862-9867, 1995.

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