Streptococcal ABC transporter protein

Details Streptococcal ABC transporter protein Streptococcal ABC transporter protein

2005-01-18

2005-01-18

Graser, Jennifer E. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S185100, C424S190100, C530S300000, C530S350000

Reexamination Certificate

active

06843999

ABSTRACT:
A polypeptide suitable for use in vaccination against Streptococcal infections comprises: a) the amino acid sequence of SEQ ID No 1; b) a variant of (a) which is capable of binding an anti-MtsA antibody; or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of binding an anti-MtsA antibody. A vaccine composition comprises: a) the amino acid sequence of SEQ ID No 1; b) a variant of (a) which is capable of generating an immune response to a Streptococcal; or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating an immune response against aStreptococcus.

REFERENCES:
patent: 5422427 (1995-06-01), Russell et al.
patent: 5854416 (1998-12-01), Sampson et al.
Embl Database Entry Accession No. M63481; M37189, Mar. 22, 1991.
Dintilhac and Claverys, “The adc locus, which affects competence for genetic transformation inStreptococcus pneumoniae, encodes an ABC transporter with a putative lipoprotein homologous to a family of streptococcal adhesions,”Res. Microbiol. 148:119-131,1997.
Ganeshkumar et al., “Nucleotide sequence of a gene coding for a saliva-binding protein (SsaB) fromStreptococcus sanguis12 and possible role of the protein in coaggregation with actinomyces,”Infection and Immunity 59(3):1093-1099, Mar. 1991.
Janulczyk et al., “Identification and characterization of aStreptococcus pyogenesABC transporter with multiple specificity for metal cations,”Molecular Microbiology 34(3):596-606, 1999.

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