Streptenols from streptomycetes, and the preparation and use the

Details Streptenols from streptomycetes, and the preparation and use the Streptenols from streptomycetes, and the preparation and use the

1990-02-22

1992-06-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568415, 435155, 435183, C07C 33035

Patent

active

051188821

ABSTRACT:
Novel streptenols with pharmacological activity, in particular with HMG-CoA-reductase inhibiting activity, can be isolated from the nutrient broth of streptomycetes. These compounds can also be used as synthesis unit for the production of mevilonin analogues.

REFERENCES:
Isoe et al., Chem Abst., vol. 102, #149,404s (1985).
Narita et al., Chem Abst., vol. 109, #169872r (1988).
Narita et al., Chem. Abst., vol. 107, #5734e (1987).
Arnone et al., Chem. Abst., vol. 110, #111,373h (1989).
Keller-Schierlein et al., "(3S, 8E)-1,3-Dihydroxy-8-decen-5-5 on, ein Stoffwechselprodukt von Streptomyces fimbriatus" (Millard und Burr 1926), Helvetica Chimica Acta-vol. 66, pp. 1253-1261.
Mizutani, S. et al., "Biological Activities of IC201 ((3S,8E)-1,3,-Dihydroxy-8-Decen-5-One), A Low Molecular Weight Immunomodulator Produced by Streptomyces", J. Antibiotics vol. 42, No. 6, Jun. 1989.
Organic Chemistry, Morrison and Boyd (eds.); p. 774; 1987.

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