Stranded RNA virus particles

Details Stranded RNA virus particles Stranded RNA virus particles

1995-09-29

1998-08-04

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 4351723, 514 44, C12N 700, C12N 701

Patent

active

057892296

ABSTRACT:
Recombinant methods for recovering wildtype or engineered negative stranded, non-segmented RNA virus genomes containing non-coding 3' and 5' regions (e.g. leader or trailer regions) surrounding one, several or all of the genes of the virus or one or more heterologous gene(s) in the form of ribonucleocapsids containing N, P and L proteins, which are capable of replicating and assembling with the remaining structural proteins to bud and form virions, or which are only capable of infecting one cell, or are transcribing particles, are disclosed. Novel vaccines, gene therapy vectors and antiviral compounds based on these viral particles are also disclosed.

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